Background: Anti-angiogenesis or inhibition of blood vessel formation is the best way to prevent the growth and metastasis of tumors. The use Morinda citrifolis L. extracts have been reported to exhibit a broad range of therapeutic effects, including antibacterial and antitumor. Objective: This study aims to investigate the anti-angiogenic properties of Morinda citrifolia L. leaves extracts using Chicken Chorioallantoic Membrane (CAM) assay. Materials and Methods: The Fertile White Leghorn eggs were divided into five groups which were control, Bevacizumab drug and treatment groups with 25%, 50% and 75% of Morinda citrifolia L. leaves extracts respectively. The reduction of the blood vessel was counted after 12 h and 24 h post-treatment. Results: Analysis have shown significant differences (P<0.05) in the reduction of the blood vessel between each group at 24 h post-treatment. The group with 75% extracts showed 37.1% reductions of blood vessel compared to groups 50% and 25% extracts which showed 4% and 12.8% respectively. The phytochemical screening has showed that Morinda citrifolia L. leaves extracts was positive for flavonoid, phenols and phytosterols. Conclusion: Morinda citrifolia L. leaves extracts consist of the phytochemical compounds that have the ability to inhibit the angiogenesis.