De Quervain tenosynovitis of the wrist is a tightening or compression along with the inflammation of the 1st dorsal compartment. Objectives: To determine the magnitude of De Quervain's Tenosynovitis, functional disability and pain association with Mobile Texting among the students of The University of Lahore. Methods: A non-probability convenience sampling strategy was used to conduct a cross-sectional research among 191 individuals from the University of Lahore. The data was obtained using the Standardized Michigan Hand Outcomes Questionnaire after informed written agreement. The Numeric Pain Rating Scale (NPRS) was used and Finkelstein's test was performed. The data was analyzed using the SPSS. For categorical data, frequency and percent-ages were used, and the chi-square test to find the relation between the variables. P-value of <0.05 was considered significant. Both male and female patients who matched the inclusion criterion of being between the ages of 22 and 32 were taken in study. Results: Out of 191 university students, 100 (52.4%) were male and 91(47.6%) were female, the age was 27 ± 0.32, dominant hand of 177 (92.67%) was right and 14 (7.33%) were left-handed. There was a positive association among Finkelstein's test and Michigan hand questionnaire (MHQ) as p < 0.001 as well as Numeric Pain Rating Scale (NPRS) and Michigan hand questionnaire (MHQ) as p<0.001. Conclusions: The study discovered that nearly significant proportion of the student’s text on their phones, and that as a consequence of their mobile phones usage and extreme texting speed and they experience De Quervain's. There is an affirmative correlation between frequent text messaging and thumb pain.