Background: Wound healing has global healthcare concept where fighting infection, rapid cure, correct epithelization with minimal scar formation and feasible potent wound dressing management is targeted through recent researches with natural products. There is a renaissance in apitherapy wound dressing especially those related to honey and propolis. The review acted with the activity of these api-products on wound healing as antimicrobial, immunomodulator, antioxidant and anti-inflammatory agents referring to some mechanism of action. Recent api-products nanofabrication wound dressings have advantages of easy applicable potent with different api-products activities and short treatment regimen especially those polymeric networks. Moreover, maintaining wound moisture suitable for fast re-epithelialization. Rather than, small diameter, high porosity, narrow diameter distribution, gas permeation.