Background: Rectal cancer accounts for the largest distribution within one anatomical region of the large bowel, with approximately one third of all CRC located within the rectum. The Golden standard treatment of primary rectal cancer is curative surgical resection; however, a fine balance remains between disease cure and restoration of gastrointestinal continuity. Combined modality has proven efficacy in many malignant tumors with advantage of organ preservation. Methods: Forty nine (49) patients with low rectal carcinoma were included in a prospective study, between Jan 2007 and Jan 2012. Preoperative chemoradiation was administrated to all patients and subjected to different techniques of sphincter saving surgery. Stage I and Stage IV disease at diagnosis were excluded from the study. Results: Forty nine patients were included in the study. 27 (55%) patients were male and 22 (45%) were female; the age ranges from 23 years to 70 years with the median age 46 years. The main presenting symptoms were bleeding per rectum and tenesmus, Stage II 18 patients (36.7%), stage III 31 patients (63.3%). Complete clinical and pathological response in 3 patients (6%), and complete clinical response with only microscopically residual carcinoma in 20 patients (41%), partial response in 18 patients (36.7%), and no significant response in 8 patients (16%) 7 from 8 were mucoid carcinoma. Low anterior resection (LAR) in 22 patients (44.9%), Hartman’s procedure in 4 patients (8.1%), Coloanal pull-through (COP) was done in 19 patients (38.9%) and perineal colostomy in 4 patients (8.1%). For patients with colo-anal pull-through technique complete dehiscent and retraction observed in 2 cases, Major leakage in one case, stenosis in 4 cases. Conclusion: There is tendency of colorectal cancers to affect younger groups. Most patients presented in advanced stage. Neadjuvant chemo radiation is an excellent tool in sphincter saving surgery. Coloanal pull-through technique is not a widely spread technique for low rectal cancer with good oncological safety and acceptable functional outcome.

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Background: High grade glioma (HGG) is the most common primary malignant brain tumor. Radiotherapy (RT) plays an important role in the treatment of this tumor. Aim: To compare the survival rates of HGG patients treated by conventional RT and those treated by hypofractionated or hyperfractionated RT combined with chemotherapy in two centers in Upper Egypt. Methods: Data of HGG patients from two cancer care facilities in Upper Egypt who were treated by surgery followed by RT and temozolomide (TMZ) in the period between 2007 and 2012 were reviewed. Radiotherapy schedules were either conventional RT (60 Gy in 30 fractions over 6 weeks, group A) or hypofractionated RT (45 Gy in 15 fractions over 3 weeks, group B) or hyperfractionated RT (64.8 Gy in, 1.2 Gy/fraction, 2 fractions/day, group C) with ± concurrent TMZ and adjuvant TMZ. Progression-free survival (PFS) and overall survival (OS) of patients after receiving the different types of RT treatment were evaluated. Results: Forty-eight patients with grade III or IV HGG were identified. They were classified into 3 groups (A, B and C) that included 17, 16 and 15 patients, respectively. The median PFS were 6, 9 and 8 months (p= 0.354) and the median OS were 11, 12 and 14 (p= 0.760) for group A, B and C, respectively. Late RT toxicity was not different between the 3 groups. Conclusion: The three radiation schedules had a similar efficacy in adult HGG patients.