In the new era, the trend of using wearable devices and smart accessories gained considerable popularity and become a necessity utility for human life due to their major role to keep monitoring health conditions and providing healthcare services. The combination of IoT networks with edge computing paradigms develops an intelligent e-health system that aims to monitor different real-time scenarios. The deployment of an e-health system exposes several challenges regarding the security and privacy aspects, particularly in the case of dealing with an enormous quantity of medical data and the risk presented by exchanging operations with external entities. In this paper a comprehensive presentation covered the basic topics of e-health system layers thus the advantages and limitations in terms of existing challenges has been mentioned, subsequently, adapted to the exposed cyber risk through the traditional systems in exchanging medical data, a discussion of the blockchain technology come over for new application opportunities, where this approach efficiently ensure the security of data transactions over the network, in addition, an overview outlined the main research works related to this technology. Therefore, a presentation study of diverse works reveals different security framework solutions related to e-health system’s layers, furthermore, uncovering the benefits of integrating intelligent technologies such as Machine Learning (supervised, and unsupervised types), Deep Learning, and Reinforcement Learning as well as introducing a comparison analysis of multiple AI algorithm models based on their efficiency for future deployment related security purposes to provide a smart healthcare monitoring system that meets patient needs. The end of this review highlighted further research directions and the actual open challenges regarding the e-Health system’s limitations.

Current health situations and crises require physicians and researchers to convert traditional healthcare services to a new generation of digital healthcare known as e-health smart systems that operate close to the end user with the objective to provide medical assistance using advanced technologies including Internet of Medical Things technology, edge computing, and cloud computing paradigms. However, this system architecture reveals limitations in terms of latency, bandwidth, power consumption as well as security and privacy of collected data. Through this paper, a presentation of different healthcare monitoring system layers has been defined, in addition to listed challenges faced by the deployment of this technology, while providing an introduction of security risks that threaten the user data safety alongside the e-health layers. Moreover, a summarized discussion of Blockchain technology came over to provide a secure decentralized architecture in sharing data across allowed entities.