Pharmaceutical product must be chemically, physically and therapeutically stable to ensure the health and preventive aspect. We have to study the effect of many factors on drug formulation as well as packaging and storage. Stability of pharmaceutical preparation act as the identity card of the drug to reach the pharmacy, the hospital, and the consumer in general, without this identity, it is not possible to approve the drug healthily or in circulation. Furthermore, stability mentoring of pharmaceutical preparations provides information about many physiochemical parameters as rate, and order of decomposition reaction of active ingredients, or the expected interaction with the other ingredients. In order to follow the stability of any pharmaceutical product, an analytical method must be available and convenient for the chemical nature of the product, the analytical procedure must be validated by the accuracy, precision, recovery as well as sensitivity, selectivity proved with statistical calculations such as t-test, and f-test.

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Cosmetics and so-called care products, whether skin or hair, are used by millions of people. Skin is the first line of defense in the human body, but in spite of this, some toxic elements in cosmetics may be able to cross and penetrate this barrier, causing serious dangers, including various types of cancer. while the knowledge of many users of these products risks is limited and should be improved. Some cosmetics contain concentrations of heavy elements exceeding the minimum limits set by the World Health WHO and FDA Organization The aim of this work is review of the analytical methods that tracked the concentrations of heavy metals such as Pb, Cd, Hg and as in cosmetics of different grades