This study was designed to demonstrate the relationship between 25-hydroxy vitamin D (25(OH)D) levels and insulin resistance (IR) in normal pregnancy and in gestational diabetes mellitus (GDM

The antioxidant, antidiabetic, radical scavenging activity of garlic oil, Vit E, and their combination were investigated in male albino Wistar rats. Forty rats were divided into five groups (n=8). One group was considered as the negative control (G1), and the rest were injected with streptozotocin for inducing diabetes and divided into 4 groups as follows. group (G2): as the positive control, (G3): treated with garlic oil, (G4): treated with Vit E, and (G5): treated with a mixture of both garlic oil and Vit E. The streptozotocin positive control group (G2) showed decreased antioxidants, high-density lipoprotein, blood glucose, lipid peroxidation, cholesterol, and triglycerides, as well as decreased lipoprotein-cholesterol densities. The treatment of diabetes in G3, G4, and G5 by garlic oil, Vit E, and their mixture, respectively enhanced the antioxidant and decreased the blood glucose, lipid profile, and lipid peroxidation. In G5, the garlic oil and Vit E combination showed better protection against streptozotocin-induced diabetes than either garlic oil or Vit E, separately.

ObjectiveThe aim of this study was to investigate the effect of coenzyme Q10 (CoQ10) supplementation on oxidative stress engendered from hypoxia in population live at high altitude.MethodsThis is an intervention study in which 50 females of volunteers population-36 of them who live at high altitude compared with the placebo group (14 from the total population that live at sea level). Blood samples were collected in -anticoagulant tubes from control and high altitude before and after CoQ10 supplementation (150 mg/day for 2, 4 and 8 weeks). Plasma was separated and used for the determination of malondialdehyde (MDA), nitric oxide (NOx), total antioxidant capacity (TAC), paraoxonase (PON1) by spectrophotometer, CoQ10 and vitamin E by high performance liquid chromatography (HPLC).ResultsOur results appeared that TAC, PON1, vitamin E and CoQ10 concentrations were significantly decreased in population at high altitude at base line compared to placebo group population at sea level. Whereas, administration of CoQ10 attenuated all measured parameters especially after eight weeks of administration.ConclusionWe concluded that coenzyme Q10 supplement at a dose of 150 mg/day has a powerful effect in oxidative stress parameters and increased antioxidant parameters included vitamin E in population with hypoxia after 4 and 8 weeks. So that supplementation positively affects oxidative stress and is recommended CoQ10 supplementation in population who live at high altitude.