Objectives: The current work aimed to study carbon monoxide (CO) related deaths in Alqurayyate during the period from 2004-2018. Methods: All medico-legally examined cases with carboxyhemoglobin [COHb] levels ≥ 10%, within the study years, were investigated. The demographic data, autopsy findings and toxicological laboratory results for the cases of interest were collected. Results: Among 461 autopsied cases, 52 cases [11.3%] show carboxy-hemoglobin (COHb) levels≥ 10%. Higher COHb levels were significantly more common among males, young and elderly and Saudi people [0.012, 0.009, and 0.3 respectively]. was the cause of death in 19 cases [4.1%] while CO poisoning was suggested as a contributing factor in another 33 [7.2%] deaths. The mode of deaths was mainly accidental [78.8%]. Houses were the most common place of death [63.5%] and most CO related deaths happened in the winter months [73.1%]. The most common suggested source for exposure to CO among carbon monoxide poisoning (COP) deaths were car exhaust [36.8%], followed by charcoal heaters [31.6%]. Regarding autopsy findings, the external appearance revealed cherry red hypostasis in only 26.9% of CO related cases. The most common findings were pulmonary edema, cerebral edema, and congested lungs [96.2,82.7, and 80.8 % respectively]. Conclusion: COP remains a common cause of death, inspite of the safety precautions. More public awareness programs about COP are recommended. Also, COHb levels should be routinely estimated in the autopsied cases, especially with suggestive history and death scene.

Objective: This experimental study aimed to evaluate the statin-induced hepatotoxicity in albino rats, as well as to compare the potential hepatotoxicity between atorvastatin and simavastatin through evaluation of both biochemical and histopathological parameters. Materials & Methods: 60 male albino rats were used in this study and were equally divided into three groups. The control group received only saline orally, the atorvastatin group which received (80 mg/kg) orally, and the simavastatin group which received simavastatin (80 mg/kg) orally. The study was conducted over a period of 12 weeks and at the end blood samples and liver tissues were obtained for assessment of biochemical markers of the liver and histopathological examination. Results: All the biochemical parameters in the current study showed higher values in the atorvastatin and simvastatin groups compared to the control group with significant probability value. The significance was detected between each of the statin groups and the control group. However no significant difference was found between atorvastatin and simvastatin group. Likewise, histopathological results showed significant hepatic injury in case of both statin groups compared to the control one. Conclusion & Recommendations: Atorvastatin and simvastatin induced hepatic injury as demonstrated by both biochemical and histopathological results in this study. Moreover, no significant difference was found between atorvastatin and simvastatin as regard statin induced liver injury.

Major pelvic fractures are predominantly observed when there is a highenergy transfer to the patient such as following road traffic collision, pedestrian accident, fall from height, or crush injury. Less serious pelvic fractures may occur with low-energy transfer events, particularly in the elderly. Objectives: The aim of the current study is to statistically assess the prevalence, common causes, management and outcome of pelvic fracture cases admitted to Kasr Al-Ainy hospital through the year 2018. Subjects and methods: The data presented in this study were obtained from the bureau of statistics at Kasr Al-Ainy hospital. One hundred ninety six cases with traumatic pelvic fractures were admitted to Kasr Al-Ainy hospital during the one year period study from January 2018 to December 2018. Results: the incidence of traumatic pelvic fractures in the present study was higher in males, urban areas and day time. The age group 21-40 was associated with a higher percentage of traumatic pelvic fractures was recorded and a mean age was 35 years. Road traffic accidents were the commonest cause followed by fall from height. A higher incidence of multiple pelvic fractures and the higher percentage of cases was treated surgically. Improvement was the major outcome while death was associated with the old age group above 61 years. Conclusion and recommendations: there is a need to decrease the number of road traffic accidents and greater precautions should be taken against the risks of fall from height. Old age group should be managed with special care.