No abstract

Context:Xeroderma pigmentosum is a rare autosomal-recessive disorder that appears in early childhood. Squamous cell carcinoma is not uncommon in patients with xeroderma pigmentosum and mostly involving the face, head, neck, and scalp. However, squamous cell carcinoma of the scalp may exhibit an aggressive course.Case Report:Here, we present a huge squamous cell carcinoma of the scalp in a three-years-old child with xeroderma pigmentosum. In addition, we illustrate the challenges of a child with xeroderma pigmentosum who grows up in a sunny environment where the possibility of early onset of squamous cell carcinoma is extremely high in any suspected skin lesion.Conclusion:In xeroderma pigmentosum patients, squamous cell carcinoma of the scalp can present early and tends to be unusually aggressive. In sunny areas, proper education to the patient and their parents about ultra-violet light protection and early recognition of any suspicious lesion could be life-saving.

Hair loss affects self-image and is a significant contributor to anxiety and depression in some men, despite the fact that male androgenetic alopecia is frequently thought of as a relatively minor dermatological problem. Male androgenetic alopecia is also considered a risk factor for several other diseases including cardiovascular diseases. It affects 30-50% of men by the age of 50. Male androgenetic alopecia is a genetically transferred disease. Midfrontal scalp, vertex and temples are the commonly affected areas. Follicular shrinkage, inflammation, and altered hair development are the main pathophysiological characteristics the disease. The anagen phase gets shorter with each cycle whereas the telogen phase stays the same length or gets longer during the course of the disease. The purpose of this research is to review the available information about the epidemiology and treatment of male androgenetic alopecia. Male androgenetic alopecia shows variable prevalence among different ages and ethnicities. Caucasians have much high reported prevalence than Asians. The prevalence of male androgenetic increases with age. Minoxidil and finasteride are the drugs of choice and most commonly used in practice for the treatment. Even while the existing therapies for androgenetic alopecia are effective in slowing the disease's progression, they only allow for partial hair restoration. Early treatment leads to the most ideal outcome. Hair transplantation remains the option if medical treatment fails. Further research can aid in developing new treatment strategies.

Radiation dermatitis is an acute skin reaction that occurs as a result of radiotherapy used to treat a range of different cancers. The severity of symptoms ranges from erythema to dry desquamation (dry, flaky skin with itching) to moist desquamation (serious exudate, edema, and blistering). While a variety of topical agents and dressings are used to ameliorate side effects, there is minimal evidence to support their use. This study aimed to review the evidence on radiation-induced dermatitis, its prophylaxis, and its management. Only a few studies have found that specific topical agents have a significant benefit. Film dressings are the most efficient means of preventing acute radiation dermatitis, whereas foam dressings were found to be beneficial in treating it. In a preventive situation, barrier films and silicone-based gel treatments may lower the severity of skin reactions and symptoms and entirely halt the onset of moist desquamation. Radiation dermatitis has been prevented and treated with a variety of topical and systemic medications, but there is not enough data to recommen