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Background: Children with severe or profound hearing loss are substantially get benefit from cochlear implantation that plays an important role in development of listening skills, communication abilities, social skills and participation and help children to progress in their life as an ability to carry out successful livelihood. Objective was to evaluate effect of empowerment program on parents' self competence regarding care of their children with cochlear implantation. Methods: A quasi-experimental design was used. This study was conducted at Phoniatric Unit of Ear, Nose and Throat department in Bahteem Specialized Hospital. A purposive sample of (75) parents accompanying their children with cochlear implantation. Four tools were used; A structured interviewing questionnaire sheet, Child medical data sheet, Parents' reported practices checklist and Parenting Sense of Competency Scale. Results: there were highly statistical significance difference in parents' knowledge, reported practice and self competence level regarding care for their children with cochlear implantation pre and post empowerment program implementation. while, there were no statistical significance difference in parents' knowledge, reported practice and self competence level regarding care for their children with cochlear implantation between post and after 3 months of empowerment program implementation.