Our proposed IQA was designed to consider MR-specific features and outperformed other no-reference IQAs designed mainly for photographic images. Magn Reson Med 80:914-924, 2018. © 2018 International Society for Magnetic Resonance in Medicine.

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We propose a deep learning-based spike sorting method for extracellular recordings. For analysis of extracellular single unit activity, the process of detecting and classifying action potentials called “spike sorting” has become essential. This is achieved through distinguishing the morphological differences of the spikes from each neuron, which arises from the differences of the surrounding environment and characteristics of the neurons. However, cases of high structural similarity and noise make the task difficult. And for manual spike sorting, it requires professional knowledge along with extensive time cost and suffers from human bias. We propose a deep learning-based spike sorting method on extracellular recordings from a single electrode that is efficient, robust to noise, and accurate. In circumstances where labelled data does not exist, we created pseudo-labels through principal component analysis and K-means clustering to be used for multi-layer perceptron training and built high performing spike classification model. When tested, our model outperformed conventional methods by 2.1% on simulation data of various noise levels, by 6.0% on simulation data of various clusters count, and by 1.7% on in-vivo data. As a result, we showed that the deep learning-based classification can classify spikes from extracellular recordings, even showing high classification accuracy on spikes that are difficult even for manual classification.

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