No abstract

Rifampicin has been a widely used antibiotic drug to treat bacterial infections, including tuberculous and nontuberculous infections, since the 1970s. 1 In addition to common adverse drug reactions such as hepatotoxicity, it is also associated with rare adverse effects, including renal injury. Although rare, several reports have been published describing the post-rifampicin acute renal failure dating back to 1976. 2 Most commonly manifesting as acute tubular necrosis (ATN) following re-administration of rifampicin; it is postulated that an immune response likely plays a role in the development of the renal failure. 3 Although reported multiple times, there are insufficient data to determine which patients are prone to renal failure post-rifampicin use and how to manage this adverse reaction. It is noted that patients taking rifampicin also may develop hemolysis, with or without renal injury. 4 This article will review a rare case report of kidney failure associated with hemolytic anemia and hepatitis following first-time administration of rifampicin and a literature review of similar articles. | CASE REPORTA 42-year-old Moroccan lady with no chronic comorbidities presented to the hospital with a 4-day history of repeated vomiting, chills, bilateral flank pain, and epigastric discomfort. Her vomiting was non-projectile, non-bilious,