Monoclonal antibodies play an increasingly important role for the development of new drugs across multiple therapy areas. The term 'developability' encompasses the feasibility of molecules to successfully progress from discovery to development via evaluation of their physicochemical properties. These properties include the tendency for self-interaction and aggregation, thermal stability, colloidal stability, and optimization of their properties through sequence engineering. Selection of the best antibody molecule based on biological function, efficacy, safety, and developability allows for a streamlined and successful CMC phase. An efficient and practical high-throughput developability workflow (100 s-1,000 s of molecules) implemented during early antibody generation and screening is crucial to select the best lead candidates. This involves careful assessment of critical developability parameters, combined with binding affinity and biological properties evaluation using small amounts of purified material (<1 mg), as well as an efficient data management and database system. Herein, a panel of 152 various human or humanized monoclonal antibodies was analyzed in biophysical property assays. Correlations between assays for different sets of properties were established. We demonstrated in two case studies that physicochemical properties and key assay endpoints correlate with key downstream process parameters. The workflow allows the elimination of antibodies with suboptimal properties and a rank ordering of molecules for further evaluation early in the candidate selection process. This enables any further engineering for problematic sequence attributes without affecting program timelines.

This paper investigates the impact of working capital management on the firm"s profitability. The research sample includes 119 non-financial listed companies on Vietnam stock market over a period of 9 years from 2010 to 2018. Two statistical approaches include Ordinary least squares (OLS) and fixed effects model (FEM) are employed to address econometric issues and to improve the accuracy of the regression coefficients. The empirical results show the negative and significant impacts of the working capital management, which measured by cash conversion cycle (CCC) and three components of the CCC including accounts receivable turnover in days (ARD), inventory turnover in days (INVD), and accounts payable turnover in days (APD) on the firm"s profitability measured by return on assets (ROA) and Tobin"s Q. It implies that firms can increase profitability by keeping the optimization of the working capital management measured by the CCC, which includes shortening the time to collect money from clients, accelerating inventory flow and hold the low payment time to creditors. Besides, the profitability of firms was impacted by the sale growth rate, firm size, leverage, and age. Therefore, this paper provides a new insight to managers on how to improve the firm"s profitability with working capital management.

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The single-jet mode in an electrohydrodynamic (EHD) system is the most desirable mode for generating uniform droplets and fibers and has many applications in numerous fields. Several studies have been carried out to enhance the performance of the EHD process focusing on this mode. In this paper, we introduce the use of a chamfered nozzle in an EHD system to greatly extend the single-jet mode's voltage range, and generally, to enhance the EHD process in terms of control capability and product quality. We carried out simulations and experiments to compare the performance of a chamfered nozzle and conventional flat-end nozzle. Both theoretical analysis and experiments demonstrate that the chamfered nozzle in an EHD system reduces the critical voltage, broadens the voltage range for the single-jet mode, and enhances homogeneity in particle and fiber generation. Furthermore, the chamfered nozzle's advantages were demonstrated in fabricating highly uniform poly(vinylidene fluoride-co-trifluoroethylene) (PVDF-TrFE) fibers for piezoelectric sensor development. Owing to the fibers' excellent quality, the sensor shows high sensitivity that can detect and differentiate between the drops of a metal bead, a water droplet, and an oil droplet. The use of a chamfered nozzle with its advantages shows potential for development of better EHD-based devices.