The COVID-19 pandemic is the most serious health crisis facing the modern world; hospital admissions have risen dramatically. Urticaria is characterized by itchy edematous papules/plaques, angioedema, and involvement of one or both of the deep dermis or subcutis. We investigated the effect of the COVID-19 pandemic on the incidence of acute and chronic urticaria, the proportions of urticaria patients among all dermatology patients before and after the onset of the pandemic, and age and sex characteristics. About 57 patients diagnosed with urticaria

Chronic spontaneous urticaria (CSU) lacks a specific trigger. The urticaria activity score (UAS) is used to evaluate disease status. Some studies have reported elevated serum levels of high-sensitivity C-reactive protein (hsCRP) in CSU patients, which is correlated with disease severity. The neutrophil/lymphocyte (N/L) ratio is a significant indicator of systemic inflammation. We investigated the potential correlation between serum levels of hsCRP and N/L ratio, as well as urticaria activity, in CSU patients. We included 52 CSU patients treated at the Dermatology Polyclinic of Beysehir State Hospital between August and October 2020, and 50 controls. The 7-day UAS were graded mild, moderate, or intense. We measured N/L ratios, erythrocyte sedimentation rates (ESRs), and the levels of hsCRP, T4, and thyroidstimulating hormone (TSH) in each group. The anti-thyroglobulin (anti-TG) and anti-microsomal antibody (anti-TPO) levels of CSU patients were also assayed. There were no significant differences in hsCRP, T4, or TSH levels between the groups; however, both the ESR and N/L ratio were significantly higher in CSU patients hsCRP

Amaç: Kronik spontan ürtiker (KSÜ) hastalarında serum resistin düzeyi ve metabolik sendrom (MetS) ilişkisini değerlendirmek. Yöntemler: Çalışmaya 42 KSÜ hastası ve 42 sağlıklı gönüllü dahil edildi. Boy, kilo, bel çevresi ve kan basıncı ölçümleri her iki grupta da değerlendirildi. Açlık kan şekeri, serum lipid düzeyleri, resistin ve tümör nekroz faktörü-alpha (TNF-α) düzeyleri venöz kan örneklerinde değerlendirildi. MetS tanısı National Cholesterol Education Program Adult Treatment Panell III tanı kriterleri ile belirlendi. Bulgular: KSÜ hastalarının 14'ünde (%33,3) ve kontrol grubunun 5'inde (%11,9) MetS saptandı. İki grup arasında MetS varlığı açısından istatistiksel olarak anlamlı fark bulundu, p=0,037. KSÜ hastalarının serum resistin düzeyleri ortalaması 1928,31±212,85 pg/mL ve kontrol grubunun serum resistin düzeyleri ortalaması 2107,60±156,71 pg/mL olarak saptandı. Her iki grup arasında serum resistin düzeyi açısından istatistiksel anlamlı fark görülmedi. KSÜ hastalarında MetS tanısı olan hastalar ile MetS tanısı olmayan hastalar arasında ürtiker aktivite skoru, hastalık süresi, otolog serum deri testi pozitifliği, serum immünoglobulin E düzeyi, otoimmünite varlığı, serum resistin ve TNF-α düzeyi açısından farklılık görülmedi. Sonuç: Çalışmamızda KSÜ hasta grubunda MetS görülme sıklığında artış olduğu saptanmıştır. Diğer taraftan KSÜ hastaları içinde MetS'yi olan ve olmayan iki grup arasında hastalık ilişkili parametreler ile serum resistin ve TNF-α düzeyi farklılık göstermemiştir. Anahtar kelimeler: Kronik spontan ürtiker, metabolik sendrom, resistin, tümör nekroz faktörü-alfa, ürtiker aktivite skoru, otolog serum deri testi Öz AbstractObjective: To evaluate the relationship between the serum resistin levels and metabolic syndrome (MetS) in chronic spontaneous urticaria (CSU) patients. Methods: In the study 42 CSU patients and 42 healthy volunteers were included. Height, weight, waist circumference, and blood pressure measurements were assesed for both of the groups. Fasting blood sugar, serum lipid levels, resistin and tumor necrosis factor-alpha (TNF-α) levels were evaluated in the venous blood samples. The metabolic syndrome (MetS) diagnosis was determined using the National Cholesterol Education Program Adult Treatment Panel III diagnostic criteria. Results: MetS was found in 14 (33.3%) CSU patients and 5 (11.9%) control subjects. There was a statistically significant difference between the two groups (p=0.037) in terms of MetS presence. It was found that the mean serum resistin levels was 1928.31±212.85 pg/ mL in the CSU patients and 2107.60±156.71 pg/mL in the control group. There was no statistically significant difference between the groups in terms of serum resistin levels. No difference was seen between the patients with and without a diagnosis of MetS regarding the urticaria activity score, duration of the disease, autologous serum skin test positivity, serum immunoglobulin E levels, presence of autoimmunity, serum resistin and TNF-α levels. Conclusion: An increased incidence of MetS in the CSU ...

Demodex, a type of mite, lives in human hair follicles. They can multiply very quickly in some conditions and then start to irritate the skin by causing skin disorders. This study aims to compare if working conditions affect the workers' Demodex prevalence so their skin health. A cross-sectional, multicentre study was conducted with three different occupational groups: Mine, Textile and Food Factory Workers (n=102). Determined industry workers who applied to our outpatient dermatology clinics with the complaint of dermatosis in three different cities were included in the study. Demodex positivity was checked by dermoscopy. Differences between categorical variables examined with Chi-square analysis and T test was used to compare continuous variables between groups. 50% Demodex positivity was found in mine workers, %45,3 in food factory workers and 66,7% in textile manufacturing workers. A high rate of Demodex positivity was observed in all three occupational groups. Although the highest positivity rate was observed in textile manufacturing workers, no signi cant difference was found between the groups (p=0.320). The overall prevalence of Demodex in female workers was statistically signi cantly higher than in male workers (p=0.029). Exposure of workers to a wide variety of factors in work environments such as textile factories and the fact that women are more sensitive to external factors may have caused the prevalence of Demodex to be higher in these groups. So, a change in the work environment or the use of suitable protective equipment may bene t the treatment of diseases caused by Demodex. But, further studies are needed with larger and various industry groups to make more certain views.