The article is devoted to the study of the problem of using available diagnostic tools for the health status of students who are engaged in physical education on the basis of a classical university using the LMS Moodle system. The goal of the study is to create diagnostic tools for the health status of the students which are in physical education using available innovative technologies. The study involved 46 students of the Kharkov National University named after V. N. Karazin aged 19-21 years who are engaged in sections of the sport games at the Department of Physical Culture (26 girls and 20 boys). Students performed health diagnostics using an open distance course based on LMS Moodle during the fall semester in the classroom and at home. The analysis of the results using innovative technologies was carried out by agreement and personal will of the participants. To solve the above goal, we set the following tasks: to analyze the available innovative technologies in the higher education system on the basis of a classical university; create an affordable system for diagnosing the health status of students involved in physical education on the basis of a classical university; introduce a system for diagnosing the health status of the students which are in physical education on the basis of a classical university in the educational process of physical education; make recommendations for the correction of the health status of students which are in physical education using available innovative technologies. The work used electronic methods for diagnosing health; methods of index assessment of health status; methods of mathematical statistics. The analysis of available innovative technologies in the higher education system on the basis of the classical university was carried out; an affordable system for diagnosing the health status of the students involved in physical education on the basis of a classical university has been created; a system for diagnosing the health status of students involved in physical education on the basis of a classical university was accomplished into the educational process of physical education; recommendations for the health status correction of the of students involved in physical education using available innovative technologies were selected. The created electronic «Health Passport», that concerns of all components of human health for monitoring the health of a classical university students’, is located in the open distance course «Fundamentals of Health and Rehabilitation», which is an interactive tool for studying the basic components of a healthy lifestyle: state of physical activity, biorhythms, features of daily energy consumption and diet analysis, diagnosis and health monitoring for all comers.

The aim of the research: identify combinations of genetic and neurohumoral factors that influence the development of true resistance to antihypertensive therapy (AHT) in patients with concomitant obesity (OB). The study included 200 patients aged 45–55 with uncontrolled hypertension and obesity. Treatment was prescribed in accordance with the European Guidelines 2018. Thiazide-like diuretics were additionally prescribed to those patients who did not reach the target blood pressure (BP) level after 3 months of dual therapy. Resistant hypertension was diagnosed in 48 patients who had an uncontrolled course of hypertension at the optimal doses of three antihypertensive drugs during the next month of their reception, while true resistance was found in 21 patients. The effectiveness of comprehensive treatment was evaluated after 6 months. The application of the logistic regression method at the stage of initial examination of patients showed that the early predictors of the formation of truly resistant hypertension in obese patients are CIMT, HOMA index and genetic polymorphism IRS-1. After treatment, the model of truly resistant hypertension in patients with obesity included indicators that influenced its formation at the pre-treatment stage, as well as the new ones: adiponectin, waist circumference and genetic polymorphism ADIPOQ. Genetic markers, insulin resistance, and vascular wall status play a leading role in the development of true resistance to AHT in obese patients. It is established that the main determinants of the formation of true resistance to AHT in patients with this comorbidity are IRS-1 polymorphism, HOMA index and CIMT.

The aim of the study was to investigate the effectiveness of different schemes of basic asthma therapy depending on the polymorphism of the LTC4 gene. Materials and methods. 181 patients with asthma were recruited to participate in the study. All patients included in the study underwent a general clinical study, spirometry, the level of asthma control was determined by Asthma control questionnaire 5 (ACQ-5), by studying the polymorphism of the LTC4 gene, it was determined that patients belong to the A/A, A/C and C/C genotypes. Results. Allelic -444C polymorphism of the LTC4-S gene (rs 730012) had the following genotype frequency among asthma patients: A/A – 77 people (42.6 %), A/C – 73 people (40.3 %) and C/C – 31 people (17.1 %). In groups of patients with genotypes A/A and A/C, during treatment with a low dose of ICS and montelukast, there was a significant improvement in FEV1 and the score according to the ACQ-5 questionnaire (asthma control level). However, in the group of patients with the C/C genotype, there were no significant changes in FEV1 and the score according to the ACQ-5 questionnaire. In the groups of patients with genotypes A/A and C/C on the background of increasing the dose of ICS to medium in a fixed combination with LABA compared with the results of treatment with low-dose ICS and montelukast, there was a significant improvement in FEV1 and asthma control – ACQ- 5. At the same time, in the group of patients with genotype A/C, there were no reliable indicators of FEV1 and ACQ-5 score changes. Conclusions. The frequency of genotypes A/A, A/C and C/C for LTC4S polymorphism in the studied population are 42.6 %, 40.3 % and 17.1 %, respectively. Patients with genotypes A/A and C/C have a significant response to treatment with a low dose of ICS and montelukast in the form of an improvement in FEV1 and ACQ-5 score. Increasing the dose of ICS up to moderate in a fixed combination with β2-LABA in groups of patients with genotypes A/A and C/C leads to a significant improvement in the FEV1, as well as in the asthma control level - ACQ-5

Introduction. The study was to assess the effectiveness of a comprehensive physical rehabilitation program based on the dynamics of the functional parameters of the respiratory and cardiovascular systems, and the tolerance of daily stress in middle--aged patients with chronic obstructive pulmonary disease (CoPd). The incidence of CoPd continues to grow, and life expectancy of the patients is shortened by an average of 8 years. Globally, losses from CoPd are projected to increase over the coming decades owing to the long-term exposure to risk factors and population aging. A significant role in improving CoPd patients condition and preventing the disease is played by physical rehabilitation. Methods. Analysis of modern scientific literature, content analysis of outpatient documentation, conclusions of X-ray examinations, anthropometric measurements, pulse oximetry, arterial tonometry, spirographic studies, 6-minute walk distance, methods of mathematical statistics. Results. A comprehensive physical rehabilitation program was developed for use in a polyclinic, which included a common set of physical exercises combined with breathing gymnastics with elements of superficial breathing, sound gymnastics, therapeutic massage, nebulizer therapy, Nordic walking. After the program application, chest excursion increased and airway patency statistically significantly improved. The exercise tolerance of the cardiovascular system increased. Conclusions. The physical rehabilitation program for middle-aged CoPd patients contributed to the economization of the respiratory system, slowing down the recovery of cardiovascular parameters, and improving the tolerance of daily exercise, which was confirmed by mathematical processing.Citation: Ruban L, Kochuieva M, Rohozhyn A, Kochuiev G, Tymchenko H, Samburg Y. Complex physical rehabilitation of patients with chronic obstructive pulmonary disease at a polyclinic stage of treatment.

Визначити та проаналізувати результати показників протимікробного імунітету у хворих з необтяженим та обтяженим перебігом алергодерматозів з використанням аутосироваток та аутоштамів Staphylococcus aureus, отриманих від хворих на атопічний дерматит (АД) та істинну екзему(ІЕ). Методи дослідження: У роботі проводилося обстеження 107 пацієнтів на АД і ІЕ, які перебували на стаціонарному лікуванні у відділенні дерматології ДУ «Інститут дерматології на венерології НАМН України» в 2016-2019 рр, яке включало в себе аналіз скарг і анамнестичних даних, оцінку тяжкості захворювання за шкалою SCORAD і EASI, проведення загальних клінічних, бактеріологічних і імунологічних досліджень. Обстеження пацієнтів було проведено в період загострення хвороби. Результати дослідження: У результаті проведених досліджень встановлено, що зміни імунологічної реактивності у пацієнтів з АД були більш вираженими, ніж у пацієнтів з ІЕ, яке проявилося значним пригніченням практично всіх показників функціональної активності лейкоцитів крові (як показників фагоцитарної реакції, так і спонтанного і індукованого НСТ-тесту) від помірного до важкого, особливо це помітно в групі хворих з важким перебігом АД. Показано, що у пацієнтів АД і ІЕ в стадії загострення спостерігається формування вторинного імунодефіцитного стану, що проявляється зниженням фагоцитарної активності лейкоцитів, що може бути показанням для включення до складу комплексного лікування імунокорекції Ключові слова: алергодерматози, клінічний перебіг, протимікробна резистентність