The SARS-CoV-2 immunoglobulin G (IgG) antibodies increase approximately 2 to 3 weeks after viral infection. The time period for which these antibodies persist and how rapidly they decay have been the subject of several studies in nonpregnant patients, sometimes with differing results. 1e4 A study in pregnant women observed that the neutralizing antibody titers remained stable throughout gestation. 5 Our study evaluated the qualitative IgG antibody responses to SARS-CoV-2 infection longitudinally throughout pregnancy in an unselected cohort shortly after the peak of the outbreak in New York to determine the frequency of waning seropositivity. STUDY DESIGN:This retrospective cohort study evaluated all the patients who had first and second trimester biochemical screening to detect fetal aneuploidy between May 2020 and June 2020 at 3 hospitals within a large integrated health system in New York and subsequently had SARS-CoV-2 antibody testing during hospitalization for delivery. During the study period, the health system policy was to perform SARS-COV-2 polymerase chain reaction testing on all the hospitalized obstetrical patients and to offer, but not require, SARS-CoV-2 antibody testing. All the included patients were pregnant at the start of the COVID-19 pandemic and delivered before the availability of the SARS-CoV-2 vaccination. For each included patient, the dried blood specimens collected in the first trimester and the serum blood specimens collected in the second trimester were retrieved from storage at -20 C and were tested for SARS-CoV-2 IgG antibodies to the nucleocapsid protein using an enzymelinked immunosorbent assay (Gold

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