BackgroundWe previously developed YouthCHAT, a youth programme for electronic screening and intervention for lifestyle risk factors and mental health issues. Our aim was to tailor the YouthCHAT package for use in a clinic catering for disadvantaged youth, assess its acceptability and utility, and develop a framework to scale-up its implementation.MethodsWe used a community-based participatory research approach to implement YouthCHAT in a rural clinic in New Zealand. Modifications to the programme were developed using an iterative process involving clinicians and patients. Electronic YouthCHAT data were collated and descriptive statistics produced. Quantitative data from post-consultation youth surveys were analysed, with thematic analyses undertaken of free text responses and staff interviews. A generic implementation framework was developed with modifiable components.ResultsThirty youth, predominantly female Māori, completed electronic screening then attended their clinician. Consultations included discussion of YouthCHAT responses, with joint problem-solving and decision-making regarding intervention. Twenty-seven (90 %) screened positive for at least one domain. Nineteen (67 %) had one to three issues. Sixteen (53 %) wanted help with at least one issue, either immediately or later. Patients gave YouthCHAT high acceptability ratings (M = 8.29/10), indicating it was easy to use, helped them think about and identify problems, talk with their doctor, and assisted their doctor to be aware of these issues. They liked that YouthCHAT kept them busy in the waiting room and gave them time to reflect on their responses, and what to discuss with their clinician. Clinicians felt that YouthCHAT was acceptable to their young patients because it was electronic and reinforced their privacy. They indicated YouthCHAT identified problems that would have not been identified in a normal consult, and improved consultations by making them faster. The clinic continues to use YouthCHAT post-study.ConclusionsA community-based participatory approach was used to engage key stakeholders (patients and clinic staff) for ‘real life’ translation of an electronic mental health and lifestyle screening and intervention package into a specific youth clinic context. Patients and staff found the programme acceptable and useful, and a framework was developed for scaled up and sustainable tailored implementation in other settings.

Cotton-surfaced nonwovens have been developed with cotton on one side or both sides of a core structure in which the cotton content varies from 41-75% of the fabric weight. The thermally bonded two or three layered laminates are soft but strong and have a hand similar to cotton knits or hydroentangled fabrics. The fabrics have also demonstrated excellent wetting, wicking rates, water adsorption and water retention properties. Although these novel fabrics have notable flexibility and extensibility as produced, a post-treatment process provides the fabrics with instantaneous elastic recoveries ranging from 83-93% from an extension of 50%. The fabrics exhibit minimal linting characteristics and would be suitable as medical isolation gowns, head covers and shoe covers, bed sheets, pillow cases and for consumer applications such as disposable underwear, towels, wipers and personal hygiene products.

SUMMARY Radish, Raphanus sativus L., is an important root crop that is cultivated worldwide. Owing to its evolutionary proximity to Arabidopsis thaliana, radish can be used as a model root crop in research on the molecular basis of agronomic traits. Pithiness is a significant defect that reduces the production of radish with commercial value; however, traditional breeding to eliminate this trait has thus far been unsuccessful. Here, we performed transcriptomics and genotype‐by‐sequencing (GBS)‐based quantitative trait locus (QTL) analyses of radish inbred lines to understand the molecular basis of pithiness in radish roots. The transcriptome data indicated that pithiness likely stems from the response to oxidative stress, leading to cell death of the xylem parenchyma during the root‐thickening process. Subsequently, we narrowed down a list of candidates responsible for pithiness near a major QTL and found polymorphisms in a radish homologue of Arabidopsis ANAC013 (RsNAC013), an endoplasmic reticulum bound NAC transcription factor that is targeted to the nucleus to mediate the mitochondrial retrograde signal. We analysed the effects of polymorphisms in RsNAC013 using Arabidopsis transgenic lines overexpressing RsNAC013 alleles as well as in radish inbred lines bearing these alleles. This analysis indicated that non‐synonymous variations within the coding sequence result in different levels of RsNAC013 activities, thereby providing a genetic condition for root pithiness. The elevated oxidative stress or hypoxia that activates RsNAC013 for mitochondrial signalling enhances this process. Collectively, this study serves as an exemplary case of translational research taking advantage of the extensive information available from a model organism.

is currently a 4th year medical student of King's College London, London, United Kingdom of a 6-year program. Hannah Suh is currently a 4thyear medical student of King's College London, London, United Kingdom of a 6-year program. Hozafa Ali is currently a 4th year medical student of King's College London, London, United Kingdom of a 6-year program.