The impact of parental history of mental disorder was not confined to elevated offspring risk of concordant disorders but rather offspring are at increased risk of a wide range of mental disorders, particularly those with 2 affected parents. Our results imply an important role for etiological factors giving rise to broad, as well as specific, familial vulnerabilities. These findings also have potential implications for diagnostic classification.

We examined a section of society in which major health and social problems frequently coexist including offending, psychopathology, and suicidal behavior. The need for developing more far-reaching national suicide prevention strategies is indicated. In particular, improved mental health service provision is needed for all people in contact with the criminal justice system, including those not found guilty and those not given custodial sentences. Our findings also suggest that public services should be better coordinated to tackle co-occurring health and social problems more effectively.

Risk of suicide in people who have perpetrated specific forms of violent or sexual criminal offenses has not been quantified accurately or precisely. Also, gender comparisons have not been possible due to sparse data problems in the smaller studies that have been conducted to date. We therefore aimed to estimate these effects in the whole Danish population over a 26-year period. By completely interlinking national criminal, psychiatric, sociodemographic and cause-specific mortality registers, we conducted a nested case-control study of more than 27,000 adult suicides, during 1981-2006, and more than half a million age and gender-matched living controls. Elevated suicide risk was found in male sexual offenders. Risk was even higher among violent offenders, with greater effect sizes seen in females. It was markedly raised with serious violence, reaching a peak in relation to homicide or attempted homicide: male odds ratio (OR) 12.0, 95% confidence interval (CI) [8.3, 17.3]; female OR 30.9, CI [11.9, 80.6]. Following adjustment for psychiatric and social risk factors, relative risk in violent offenders was comparable to that seen among nonviolent offenders. These findings underline the importance of understanding why some people are violent toward themselves as well as other people, and why suicide risk is so much higher in people who have perpetrated serious acts of violence. They also indicate a clear need for developing effective multiagency interventions that effectively tackle both forms of destructive behavior.

Women with high levels of T. gondii-specific IgG antibodies have a significantly elevated risk of developing schizophrenia spectrum disorders.

No abstract