This study reports a strategy involving biocatalysis to form 2-alkylbenzoxazoles and 2-arylbenzoxazoles specifically via the urease-artificial Vitreoscilla hemoglobin metalloenzyme (ArVHbM)-catalyzed cascade reaction of urea, catechols, and aldehydes. In this system,...

In this study, supercritical carbon dioxide (ScCO2), which is a sustainable and green solvent, was used as a reaction medium in the lipase‐catalyzed synthesis of anthrone‐functionalized benzylic amines for the first time. We synthesized the target compounds via a lipase‐catalyzed multicomponent cascade reaction of aldehydes, sulfonamides, and anthrones in ScCO2. The reaction can be accomplished in good‐to‐excellent yields (77 %–95 %) and can exhibit good functional group tolerance. In brief, the reaction was characterized by step economy, metal‐free conditions, environmentally friendly solvents, and biocatalysts.

The development of non-natural enzymatic catalysis is important for multicomponent tandem organic transformations. However, the delicate acting environments of biological enzymes still present some challenges in the synthesis of spirooxindole skeleton via enzymatic catalysis. To address these issues, a lipase-catalyzed method was developed for the synthesis of spirooxindole frameworks. Using easily available isatins, cycloketones, and malononitriles as substrates, mild reaction conditions, and a reasonable reaction time, moderate to good yields (67–92%) and excellent functional group tolerance were accomplished via this protocol. The related mechanism explanation is also speculated in this paper.

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With the rapid development of science and technology, the application of Virtual Reality (VR) technology is becoming more and more widespread. With its immersion, interactivity and expandability, VR technology has become a promising technology with broad application prospects. Therefore, this paper aims to investigate the factors that influence user experience in the design of user interface in VR environment, and to summarize the key points of VR user interface design in different application areas. The article will take interface design and user experience as the starting point to compare different user interface modes and their impact on user experience in VR environment; meanwhile, the design points of VR user interface in education field and game field and the impact factors on user experience in different scenarios are compared and summarized respectively. The final part of the article summarizes the user interface in VR environment in education and game field, and provides an outlook on the future improvement and enhancement of user experience in VR scenario.