This work provided initial evidence that the methanol and ethanol extract of Syzygiumcumini seeds polyphenol compounds are separated. The major polyphenolic compounds are determined and its derivatives posses strong amylase and tryosinase inhibitory activities with IC 50 values more than 50μg/ml for amylase and more than 80μg/ml for tryosinase respectively. Such half maximal inhibitory concentration (IC50) values substantiate to manage diabetes and neuroprotective effects in patients to minimize the secondary complications associated with diabetes and melanogenesis.