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Nasopharyngeal carcinoma (NPC) is an Epstein-Barr virus (EBV)-associated cancer characterized by a high degree of recurrence, angiogenesis, and metastasis. The importance of alternative pro-angiogenesis pathways including viral factors has emerged after decades of directly targeting various signaling components. Using NPC as a model, we identified an essential oncogenic pathway underlying angiogenesis regulation that involves the inhibition of a tumor suppressor, Spry3, and its downstream targets by EBV-miR-BART10-5p (BART10-5p) and hsa-miR-18a (miR-18a). Overexpression of EBV-miR-BART10-5p and hsa-miR-18a strongly promotes angiogenesis in vitro and in vivo by regulating the expression of VEGF and HIF1-α in a Spry3-dependent manner. In vitro or in vivo treatment with iRGD-tagged exosomes containing antagomiR-BART10-5p and antagomiR-18a preferentially suppressed the angiogenesis and growth of NPC. Our findings first highlight the role of EBV-miR-BART10-5p and oncogenic hsa-miR-18a in NPC angiogenesis and also shed new insights into the clinical intervention and therapeutic strategies for nasopharyngeal carcinoma and other virus-associated tumors.

A new record for high-finesse silica waveguide ring resonators (WRRs), to the best of our knowledge, is demonstrated experimentally. The achieved finesse and resonant depths of the silica WRR with a length of 7.9 cm and a diameter of 2.5 cm are 196.7% and 98%, respectively. In addition, the silica WRR chip is coupled with single-polarization fiber to improve the polarization extinction ratio (PER) and, thus, to reduce the polarization error. With the application of this high-finesse and high-PER WRR to the resonant micro-optic gyroscope (RMOG), a bias stability of 0.004°/s is observed over a 1 h timeframe. To the best of our knowledge, this is the first RMOG reported in the open literature that can sense the earth's rotation rate (15°/h).