In plasmas with a large ratio of plasma frequency to gyrofrequency (ω pe/Ωce), energetic electrons characterized by can excite electron cyclotron maser instability (ECMI), generating waves of upper hybrid (UH), Z, and W modes. It has been presumed that these ECMI waves can somehow convert to escaping X–O modes as fundamental (F) or harmonic (H) plasma emission. Here we perform a fully kinetic, electromagnetic particle-in-cell simulation to investigate the proposed radiation process. ECMI is driven by energetic electrons with a Dory–Guest–Harris distribution representative of a double-sided loss cone, and ω pe/Ωce is set to be 10. We find that the electrostatic UH mode is the fastest-growing mode. Around the time when its energy starts to decline, the W mode grows to be dominant. During this stage, we observe significant F and H plasma emission. The F emission is in the O mode with a bandwidth around 0.1–0.2 Ωce, and the H emission is contributed by both X and O modes with a narrower bandwidth. We suggest that the O–F emission is caused by coalescence of almost counterpropagating Z and W modes, while the H emission arises from coalescence of an almost counterpropagating UH mode at relatively large wave number. Thus the plasma emission investigated here is induced by a combination of wave growth due to ECMI and further nonlinear wave-coupling processes. The result is relevant to understanding solar radio bursts as well as other astronomical radio sources that are excited by energetic electrons trapped within certain magnetic structures.

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Background:Hepatocellular carcinoma (HCC) is a primary malignancy of the liver. New serum biomarkers for HCC screening are needed, especially for alpha-fetoprotein (AFP) negative patients. As a proximal fluid between body fluids and intracellular fluid, tissue interstitial fluid (TIF) is a suitable source for serum biomarker discovery.Methods:Sixteen paired TIF samples from HCC tumour and adjacent non-tumour tissues were analysed by isobaric tags for relative and absolute quantitation (iTRAQ) method. Two proteins were selected for ELISA validation in serum samples.Results:Totally, 3629 proteins were identified and 3357 proteins were quantified in TIF samples. Among them, 232 proteins were significantly upregulated in HCC-TIF and 257 proteins down-regulated. Two overexpressed extracellular matrix proteins, SPARC and thrombospondin-2 (THBS2) were selected for further validation. ELISA result showed that the serum levels of SPARC and THBS2 in HCC patients were both significantly higher than those in healthy controls. The combination of serum SPARC and THBS2 could distinguish HCC (AUC=0.97, sensitivity=86%, specificity=100%) or AFP-negative HCC (AUC=0.95, sensitivity=91%, specificity=93%) from healthy controls. And the combination of serum SPARC and THBS2 could also distinguish HCC patients from benign liver disease patients (AUC=0.93, sensitivity=80%, specificity=94%). In addition, serum THBS2 was found to be a novel independent indicator for poor prognosis of HCC.Conclusions:Novel HCC candidate serum markers were found through in-depth proteomic analysis of TIF, which demonstrated the successful utility of TIF in cancer serum biomarker discovery.

Source imaging of solar radio bursts can be used to track energetic electrons and associated magnetic structures. Here we present a combined analysis of data at different wavelengths for an eruption associated with a moving type-IV (t−IVm) radio burst. In the inner corona, the sources are correlated with a hot and twisted eruptive EUV structure, while in the outer corona the sources are associated with the top front of the bright core of a white light coronal mass ejection (CME). This reveals the potential of using t−IVm imaging data to continuously track the CME by lighting up the specific component containing radio-emitting electrons. It is found that the t−IVm burst presents a clear spatial dispersion with observing frequencies. The burst manifests broken power-law like spectra in brightness temperature, which is as high as 10 7 -10 9 K while the polarization level is in-general weak. In addition, the t-IVm burst starts during the declining phase of the flare with a duration as long as 2.5 hours. From the differential emission measure analysis of AIA data, the density of the T-IVm source is likely at the level of 10 8 cm −3 at the start of the burst, and the temperature may reach up to several MK. These observations do not favor gyro-synchrotron to be the radiation mechanism, yet in line with a coherent plasma emission excited by energetic electrons trapped within the source. Further studies are demanded to elucidate the emission mechanism and explore the full diagnostic potential of t-IVm bursts.

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