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Analyzing the seasonal variation of water quality, the indices which include total iron, pH, temperature, DO, alkalinity and hardness were of high statistical significance, and total iron had a high correlation with temperature, which influences many parameters influencing iron release, such as DO, solution viscosity, thermodynamic properties and microbial activity. Therefore, it can be concluded that temperature is a main factor that affects iron release in seasonal change for drinking water distribution systems. Variation in season and temperature should be paid attention to in practice of water supply.