Background: Dysbindin-1 isoforms are selectively reduced in schizophrenic brains. Results: Dysbindin-1C is required for the survival of hilar mossy cells and the maturation of adult newborn neurons in the dentate gyrus. Conclusion: Dysbindin-1C, but not -1A, regulates adult hippocampal neurogenesis in a non-cell autonomous manner. Significance: Reduced dysbindin-1C in the schizophrenic hippocampal formation likely contributes to the development of cognitive deficits.

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