Flexible sensor arrays are widely used for wearable physiological signal recording applications. A high density sensor array requires the signal readout to be compatible with multiple channels. This paper presents a highly-integrated remote health monitoring system integrating a flexible pressure sensor array with a multi-channel wireless readout chip. The custom-designed chip features 64 voltage readout channels, a power management unit, and a wireless transceiver. The whole chip fabricated in a 65 nm complementary metal-oxide-semiconductor (CMOS) process occupies 3.7 × 3.7 mm2, and the core blocks consume 2.3 mW from a 1 V supply in the wireless recording mode. The proposed multi-channel system is validated by measuring the ballistocardiogram (BCG) and pulse wave, which paves the way for future portable remote human physiological signals monitoring devices.