In this paper, we propose a novel laser-inertial odometry and mapping method to achieve real-time, low-drift and robust pose estimation in large-scale highway environments. The proposed method is mainly composed of four sequential modules, namely scan pre-processing module, dynamic object detection module, laser-inertial odometry module and laser mapping module. Scan pre-processing module uses inertial measurements to compensate the motion distortion of each laser scan. Then, the dynamic object detection module is used to detect and remove dynamic objects from each laser scan by applying CNN segmentation network. After obtaining the undistorted point cloud without moving objects, the laserinertial odometry module uses an Error State Kalman Filter to fuse the data of laser and IMU and output the coarse pose estimation at high frequency. Finally, the laser mapping module performs a fine processing step and the "Frame-to-Model" scan matching strategy is used to create a static global map. We compare the performance of our method with two state-ofthe-art methods, LOAM and SuMa, using KITTI dataset and real highway scene dataset. Experiment results show that our method performs better than the state-of-the-art methods in real highway environments and achieves competitive accuracy on the KITTI dataset.