Using broad-spectrum antibiotics for microbial infection may cause flora disequilibrium, drug-resistance, etc., seriously threatening human health. Here, we design a human defensin-6 mimic peptide (HDMP) that inhibits bacterial invasion in vivo through mimicking the mechanisms of human defensin-6 with high efficiency and precision. The HDMP with ligand and self-assembling peptide sequence recognizes bacteria through ligand-receptor interactions and subsequently traps bacteria by an in situ adaptive self-assembly process and resulting nanofibrous networks; these trapped bacteria are unable to invade host cells. In four animal infection models, the infection rate was markedly decreased. Notably, administration of HDMP (5 mg/kg) nanoparticles increased the survival rate of mice with methicillin-resistant S. aureus bacteremia by as much as 100%, even more than that of vancomycin treatment (5 mg/kg, 83.3%)–treated group, the golden standard of antibiotics. This biomimetic peptide shows great potential as a precise and highly efficient antimicrobial agent.
Recently, MOF-derived (metal-organic framework) 2D materials, due to the special structure of the MOF inherited, have become a potential candidate for application in energy storage and conversion. In this work, a new 2D layered CoÀ MOF was synthesized as the precursor for fabricating Napoleon-like Co 3 O 4 (NLÀ Co 3 O 4). The monolayer thickness of NLÀ Co 3 O 4 is approximately 70 nm. The unique structure of layered porous of NLÀ Co 3 O 4 derived from CoÀ MOF plays an important role in improving electrochemical and electro-catalysis properties. As lithium ion battery anode material, NLÀ Co 3 O 4 shows out-bound cycling performance and rate capacity, which has an unprecedented high reversible capacity of 1120.5 mA h g À 1 at 200 mA g À 1 after 300 cycles and high rate capacities of 579.4 mA h g À 1 under the current density of 6.4 A g À 1. NLÀ Co 3 O 4 still exhibits capacity of 679 and 576 mA h g À 1 after 200 cycles at high current densities of 1 and 4 A g À 1 , respectively. Moreover, NLÀ Co 3 O 4 has efficient oxygen evolution reduction (OER) catalytic performance (overpotential, ca. 420 mV), comparable with commercial RuO 2. During the process of continuous catalysis of OER, NLÀ Co 3 O 4 shows good durability for about 15 h.
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