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Biochemical synthesesBiochemical syntheses O 0035 Practical Asymmetric Enzymatic Reduction Through Discovery of a Dehydrogenase-Compatible Biphasic Reaction Media. -First protocol for asymmetric enzymatic reduction of poorly water-soluble substrates is developed based on the discovery of H 2 O/hexane as a solvent system in which both the alcohol dehydrogenase and the formate dehydrogenase (needed for in situ recycling of the cofactor NADH) remain stable. -(GROEGER*, H.; HUMMEL, W.; BUCHHOLZ, S.; DRAUZ, K.; NGUYEN TIEN VAN; ROLLMANN, C.; HUESKEN, H.; ABOKITSE, K.; Org.

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For Abstract see ChemInform Abstract in Full Text.

Dehydrogenase. -Poorly water-soluble ketones are reduced under conditions A) in a biphasic medium. Alcohols are obtained with high enantioselectivities. The new method can be applied as a simple access to optically active alcohols on lab scale. -(GROEGER*, H.; HUMMEL, W.; ROLLMANN, C.; CHAMOULEAU, F.; HUESKEN, H.; WERNER, H.; WUNDERLICH, C.; ABOKITSE, K.; DRAUZ, K.; BUCHHOLZ, S.; Tetrahedron 60 (2004) 3, 633-640; Degussa AG, D-63403 Hanau, Germany; Eng.) -Adam