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The world is already facing the devastating effects of the SARS-CoV-2 pandemic. A disseminated mucormycosis epidemic emerged to worsen this situation, causing havoc, especially in India. This research aimed to perform a multitargeted docking study of marine-sponge-origin bioactive compounds against mucormycosis. Information on proven drug targets and marine sponge compounds was obtained via a literature search. A total of seven different targets were selected. Thirty-five compounds were chosen using the PASS online program. For homology modeling and molecular docking, FASTA sequences and 3D structures for protein targets were retrieved from NCBI and PDB databases. Autodock Vina in PyRx 0.8 was used for docking studies. Further, molecular dynamics simulations were performed using the IMODS server for top-ranked docked complexes. Moreover, the drug-like properties and toxicity analyses were performed using Lipinski parameters in Swiss-ADME, OSIRIS, ProTox-II, pkCSM, and StopTox servers. The results indicated that naamine D, latrunculin A and S, (+)-curcudiol, (+)-curcuphenol, aurantoside I, and hyrtimomine A had the highest binding affinity values of −8.8, −8.6, −9.8, −11.4, −8.0, −11.4, and −9.0 kcal/mol, respectively. In sum, all MNPs included in this study are good candidates against mucormycosis. (+)-curcudiol and (+)-curcuphenol are promising compounds due to their broad-spectrum target inhibition potential.

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Most multiple access schemes provide orthogonal access to the users in time, frequency, code and space, this is not true for NOMA, where each user operates in the same band and at the same time where they are distinguished by their power levels. It uses superposition coding at the transmitter such that the successive interference cancellation (SIC) receiver can separate the users both in the uplink and in the downlink channels. The users in (NOMA) are classified based on power, while in Orthogonal Multiple Access (OMA) it is classified based on time, frequency, and code. The NOMA system contains a power-delay tradeoff and hence power efficiency becomes critical for Ultra-Reliable Low Latency Communication (URLLC), especially where a huge number of devices are battery-powered. Combining these considerations, we simulate Dynamic Power Allocation (DPA) for power domain non-orthogonal multiple access (PD-NOMA) with user mobility. For small and clumsy battery-powered IoT devices, power efficiency becomes critical. Further, flexibility is also important to communicate with diverse machine-type devices as well as human users while meeting a variety of quality of service (QoS) requirements. The performance of the DPA is compared with Static Power Allocation under user mobility.

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