Substituted amidines (1,2) where prepared from the condensation of benzyl, furfuryl alcohols and ethyl sulphate with thiourea. Chalcone compounds (3,5a and 5b) where also prepared from condensation of 4nitrobenzaldehyde to give compound (3) while acetophenone, 4-hydroxy benzaldehyde and 1,3-dibromopropane gave the diformyl intermediate (4) then it was underwent further reaction with either acetophenone or 4methyl acetophenone to afford compounds (5a,5b) respectively. Condensation of the above amidines with the resulted chalcones or dichalcones afforded the substituted pyrimidines (6-11).Their structures confirmation were studied by IR and were discussed.

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It is well known from FDA reports that More than 75% of the heterocyclic compounds are drugs and 90 of heterocyclic compounds are cancer drugs. The nitrogen-based heterocycles occupy an exclusive position as a valuable source of therapeutic agents in medicinal chemistry. Most drugs approved by the FDA and currently available in the market are nitrogen-containing heterocyclic moieties, More over heterocyclic compounds are important class of organic chemistry due to their widely spread in nature. Also there are many route for their action and many mechanistic pathways for their preparation and different metabolic actions. This comes from the easily building or removal of any functional group within the molecules. Changing just on group cause to change the metabolic pathway of the drug action and site of attack of the desired target accordingly. This great characteristic value make them much more important in drug discovery programs of many researchers and also encouraged us and drew attentions of other researchers to develop new ways for their synthesis. As a result different pharmacological and medical applications. Oxazie compounds are sub branch of heterocyclic compounds. These compounds having two hetero atoms, Oxygen and nitrogen within their structures make them much more important toward therapeutic studies. We are here in our investigation will focus on the methodologies and the therapeutic action of the titled compounds as well as other various applications.

Novel set of hippuric hydrazones (6-9) bearing indole and quinoline moieties were synthesized in three steps following the protocol of microwave irradiation and solvent-free conditions. The first series were synthesized by irradiate ethyl hippurate (3) with 1H-indole-6-carbaldehyde (4) under solvent-free conditions. The second series were synthesized by irradiate ethyl hippurate (3) with substituted 2-oxo-1,2-dihydroquinoline-3-carbaldehyde (5) under solventfree conditions. This work aims to develop new synthetic route of hippuric hydrazones which may possess a promising biological activities against covid-19. The formation of the prepared heteroaromatic hydrazones were approved by spectral 1H NMR, IR and mass data