Introduction:
Cervical cancer is the 4th most prevalent cancer in women worldwide. Mortalities and morbidities are still increasing despite its preventability. The knowledge, attitude and behaviour of women in fighting cervical cancer are very important.
Objective:
This study aims to record knowledge, attitude, and behaviour of women in reproductive age regarding cervical cancer at Makasar District Primary Health Care Centre, East Jakarta in 2018
Material and Methods:
Descriptive cross-sectional study was conducted. Knowledge, attitude, and behaviour of cervical cancer were obtained using an assisted interview and recorded. The receipt of services towards cervical cancer prevention is referred to be favourable and unfavourable
Results:
Of the total 105 samples, the mean age was 30 years and mostly graduated from Junior High School (66.7%). More than half (59%) participants had poor knowledge about cervical cancer, but 89% of the participants had favourable attitude in receipt of services towards cervical cancer prevention. Despite the poor knowledge, 21.9% of the participants had been screened before.
Conclusion:
The knowledge and behaviour towards cervical cancer among women in Makasar Primary Health Care Centre are still inadequate but have favourable attitude.
Maintaining the quality of life by preserving ovarian function in premenopausal patients with cervical cancer undergoing radiation is crucial. This can be accomplished with a simple and safe laparoscopic ovarian transposition procedure. This procedure aims to move the ovary out of the irradiation field, protecting it from direct radiation and irreversible damage and preserving its function. However, this procedure is often forgotten and seldom offered to patients. This review aims to lay stress on and reconsider the importance of laparoscopic ovarian transposition as a simple, safe, and extremely useful procedure. The biological effects of radiation are described briefly and several studies are evaluated, which reveal that this procedure has more benefits than risks.
Oxidative stress is considered an important factor in the development of endometriosis, including its malignant transformation. Previous studies have found that AT-rich interactive domain 1A (ARID1A), a tumor suppressor gene, is frequently mutated and inactivated in endometriosis-associated ovarian cancer (EAOC), and such a change in this gene is considered an early event in malignant transformation. We observed oxidative stress status by measuring the activity of the antioxidant enzyme manganese superoxide dismutase (MnSOD), malondialdehyde (MDA), and ARID1A gene expression in tissue samples from patients with endometriosis, EAOC, or non–endometriosis-associated ovarian cancer (non-EAOC). We also induced oxidative stress in the cultured cells from patients with primary endometriosis by adding H2O2 and tested for any alteration of ARID1A gene expression based on different H2O2 concentrations. The results showed that MnSOD activity in endometriosis and EAOC was lower than in non-EAOC, but MDA levels were higher. This study also showed that oxidative stress reduced ARID1A gene expression.
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