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A sthma is a prevalent and heterogeneous disease that not only has a marked effect on the quality of life of affected patients but also imparts a signifi cant economic burden on society. The term "refractory asthma" (RA) is used for patients with persistent asthma symptoms in whom comorbidities have been treated, triggers addressed, compliance with treatment evaluated, and alternative diagnoses excluded. 1 The link between bacterial processes and RA has emerged as various phenotypes of chronic asthma with persistent infl ammation have been recognized. [2][3][4][5][6][7] Many studies have implicated Mycoplasma pneumoniae (Mp) in the initiation and persistence of asthma, although the precise role it plays and its pathogenic mechanisms remain elusive. 8 However, several limitations exist in studies of Mp in asthma, including the inability to consistently culture this organism, the poor performance of Mp serology in defi ning active infection, and the variable sensitivities of polymerase chain reaction (PCR) assays in detecting Mp.Recently, our group identifi ed a 68-kDa protein unique to Mp called the community-acquired respiratory distress syndrome toxin (CARDS Tx). CARDS Tx is a highly immunogenic protein that possesses Abbreviations: CARDS Tx 5 community-acquired respiratory distress syndrome toxin; ELISA 5 enzyme-linked immunosorbent assay; Mp 5 Mycoplasma pneumoniae ; P1 5 P1 adhesin; PCR 5 polymerase chain reaction; RA 5 refractory asthma; rCARDS Tx 5 recombinant community-acquired respiratory distress syndrome toxin; rP1 5 recombinant P1 adhesin immunodominant carboxy domain

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Altering the morphology of electrochemically active nanostructured materials could fundamentally influence their subsequent catalytic as well as oxygen evolution reaction (OER) performance. Enhanced OER activity for mixed-metal spinel-type sulfide (CuCo2S4) nanorods is generally done by blending the material that has high conductive supports together with those having a high surface volume ratio, for example, graphitic carbon nitrides (g-C3N4). Here, we report a noble-metal-free CuCo2S4 nanorod-based electrocatalyst appropriate for basic OER and neutral media, through a simple one-step thermal decomposition approach from its molecular precursors pyrrolidine dithiocarbamate-copper­(II), Cu­[PDTC]2, and pyrrolidine dithiocarbamate-cobalt­(II), Co­[PDTC]2 complexes. Transmission electron microscopy (TEM) images as well as X-ray diffraction (XRD) patterns suggest that as-synthesized CuCo2S4 nanorods are highly crystalline in nature and are connected on the g-C3N4 support. Attenuated total reflectance–Fourier-transform infrared (ATR-FTIR), X-ray photoelectron spectroscopy (XPS), and Raman spectroscopy studies affirm the successful formation of bonds that bridge (Co–N/S–C) at the interface of CuCo2S4 nanorods and g-C3N4. The kinetics of the reaction are expedited, as these bridging bonds function as an electron transport chain, empowering OER electrocatalytically under a low overpotential (242 mV) of a current density at 10 mA cm–2 under basic conditions, resulting in very high durability. Moreover, CuCo2S4/g-C3N4 composite nanorods exhibit a high catalytic activity of OER under a neutral medium at an overpotential of 406 mV and a current density of 10 mA cm–2.