The present study deals with the evaluation of potential effects of Eclipta alba (EA) in memory impairment of mice. Memory impairment was induced by scopolamine (3 mg/kg, i.p) in animals. To assess learning and memory in mice Morris water maze test was employed. The acetylcholinestrase enzyme (AChE) activity in brain was measured to evaluate the central cholinergic activity. The levels of thiobarbituric acid-reactive species (TBARS) and reduced glutathione (GSH)in brain were estimated to assess the degree of oxidative stress. Scopolamine treatment produces significant impairment of learning and memory in mice, as reflected by a significant decrease in MWM performance. Scopolamine also produced a significant enhancement of brain AChE activity and brain oxidative stress (increase in TBARS and decrease in GSH) levels. EA (300 and 600 mg/kg,oral) significantly prevented scopolamine-induced learning and memory deficits along with decrease of scopolamine-induced rise in brain AChE activity and brain oxidative stress levels. It may be concluded that Eclipta alba has significant protective action against scopolamine induced memory deficits in mice that can be attributed to its anti AChE and anti oxidant actions. Keywords:  Alzheimer disease, Oxidative stress, Morris water Maze, Scopolamine

The aim of the study is protective effect of compound Eclipta alba and Ocimum sanctum on Parkinsonism induced mice by haloperidol injection. Parkinsonism is neurodegenerative disease due to the deficiency of dopamine in brain. The pathological hallmark of Parkinson’s disease in the cell loss within substantia nigra pars compacta (SNpc) region and the disease is charactrised by bradykinesia, rigidity, postural instability, orofacial dyskinesia, muscular stiffness and tremor1. Mice were injected 1mg/kg haloperidol and then treated with test and standard substance for 15 days. The impairment in catatonia in mice were tested using catatonic activity. Biochemical analysis of brain homogenate was performed so ass to assess brain Thiobarbituric acid reactive substance (TBARS) level and reduced glutathione (GSH) and TNF-α level were measured to assess total oxidative stress. EA 300mg/kg and OS 400mg/kg show slightly change in catatonic activity in mice while EA 600mg/kg and 800mg/kg significantly change in catatonic activity. Furthermore, Eclipta alba and Ocimum sanctum prevent the haloperidol induced changes in the level of brain TBARS, GSH and TNF-α. From the results we conclude that Eclipta alba and Ocimum sanctum has protective action against impairment in catatonic activity and pathological damage due to oxidative stress induced by intraperitoneally injection of haloperidol in mice.        Keywords: Eclipta alba, Ocimum Sanctum, Parkinsonism, Anti-oxidant.

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Coronavirus particles contain four main structural proteins. These are the spike (S), membrane (M), envelope (E), and nucleocapsid (N) proteins, all of which are encoded within the 3' end of the viral genome. The S protein (~150 kDa) utilizes an N-terminal signal sequence to gain access to the ER, and is heavily N-linked glycosylated. In view of the increase in death due to COVID-19 (coronavirus disease), it is important to investigate the potential effects the coronavirus on different organs. A literature search was performed from Elsevier, Pubmed, Springer, and Hindawi, and literature is reviewed using customized search strategies. The search strategy included the following terms Cardiovascular effect, Neurological effect, and kidney. Myocardial damage is a common occurrence in patients with COVID-19 disease hospitalisation. This is characterized by a rise in troponin. Vascular endothelial damage in both small and mid-sized pulmonary vessels was noted together with Disseminated intravascular coagulation (DIC), Deep vein thrombosis (DVT), and Pulmonary embolism (PE), resulting in pulmonary infarction. Liver damage in patients with coronavirus infections might be directly caused by the viral infection of liver cells. Neuronal pathway is an important vehicle for neurotropic viruses to enter the CNS (Central Nervous system). Recent research studies show that apoptosis is implicated in a variety of ocular disorders, including glaucoma, retinitis pigmentosa, cataract development, retinoblastoma, retinal ischemia, diabetic retinopathy, and ocular murine glaucoma. The more the understanding about this new virus and its occurrence, the better the ability of people to cope with it. It's far hoped that we will conquer COVID-19 soon with the invention of powerful vaccines, pills, and remedies.