Conflicts of interest statement: The authors declare no potential conflicts of interest. For information, NC and MJM are developing and validating the technical and clinical performance of the non-invasive blood-based miRNA test described in this manuscript. RA is assisting NC and MJM in translating the test into clinical practice. HA, CB, DC, MF, and KT worked with RA to identify potential healthcare savings following future implementation of the miRNA test.