Background: Myxomas are commonest cardiac tumors mostly seen in left atrium. However, left atrial myxoma presenting with stroke is rare clinical condition whose etiology is unknown. Case Report: A 36-year-old female presented with left-sided hemiplegia for past 2 weeks along with headache for initial 2 days. She was diagnosed to be having stroke secondary to left atrial myxoma. Conclusion: The diagnosis of left atrial myxoma can be elusive, especially when the symptoms suggest a systemic illness. The significance of symptoms becomes apparent when the patient presents acutely with a motor deficit as a result of cerebrovascular embolism. We emphasize that patients with motor deficit should be carefully followed up for atrial myxoma.