Lymphomas are a group of malignant blood cell tumors that develop from lymphocytes. Two main categories of lymphomas are Hodgkin and non-Hodgkin lymphomas (NHL), of which 90% are of the NHL type. The objectives of classifying is to help in the identification of homogenous group of well-defined entities and facilitating the recognition of uncommon diseases that further require classification as it affects prognosis and therapeutic implications. Nodal marginal zone lymphoma, also known as monocytoid B–cell lymphoma (MBCL), is an uncommon form of lymphoma representing 1.5%–1.8% of lymphoid neoplasms, with only rare reports in the literature that have attempted morphologic or immunophenotypic characterization. Specific markers for MBCLs are still lacking, so its diagnosis is based on exclusion of other small B-cell lymphomas. This article illustrates a case report of MBCL highlighting the intricacies and difficulties involved in establishing a diagnosis.

Intraoral extranodal Hodgkin's lymphoma is rare. We present the case of a 66‐year‐old gentleman who was treated for necrotizing ulcerative gingivitis of the UR6 tooth by his dentist which failed to resolve. Biopsy and histopathology revealed that this was, in fact, a rare presentation of primary (Stage I) extranodal oral Hodgkin's lymphoma. We present this case, and a review of the relevant literature.

Lymphomas are a group of malignant blood cell tumors that develop from lymphocytes representing 2.2% of all malignant neoplasms of the head and neck. Two main categories of lymphomas are Hodgkin's lymphoma and non-Hodgkin's lymphoma (NHL) of which 90% are of the NHL type. Several classification systems have existed for lymphomas, the objectives of which are to help in identification of homogeneous group of well-defined entities and facilitating the recognition of uncommon diseases that require further classification as it affects prognosis and therapeutic implications. Diffuse large B-cell lymphoma (DLBCL) is the most common NHL in the oral cavity involving Waldeyer's ring, base of the tongue, buccal mucosa and hard palate. DLBCL can be divided into germinal center B-cell-like, activated B-cell-like or type 3 gene expression profiles. This paper highlights a case report of DLBCL revisiting the intricacies and difficulties involved in establishing a diagnosis.

Background: About a quarter of patients with colorectal carcinoma develop colorectal liver metastases. Surgical treatment with curative intent by hepatic resection is the standard medical care. Frequently, new liver metastasis appear during the course of their disease. Liver re-resections are usually complicated, but they represent the treatment of choice for patients with recurrent liver metastases, survival rates being similar to those achieved after the first liver resection. Methods: We present a case of a 61-year-old man with achondroplasia and history of colorectal sigmoid cancer (pT4bN0), treated with laparoscopic sigmoidectomy with and anastomosis. He was then reoperated for anastomotic leak via laparotomy and performing a terminal colostomy. Afterward, he received chemotherapy and four months later a lesion in segment 6 compatible with liver metastasis is detected. Results: In the first video we show the laparoscopic intervention of the liver metastasis. A tourniquet is placed for the Pringle manoeuvre in case it'd be needed. A minimal mobilization of the liver was performed exclusively sectioning the round and falciform ligaments. The operation is guided with indocyanine green administration 24 hours before. That makes us possible to identify the lesion and discard the presence of others lesions. A partial resection of segment 6 is performed. The specimen was removed from an enlargement of the midline 12mm port. The intervention is completed in 80 minutes, achieving a negative margin, with minimal blood loss and without the need to execute the Pringle manoeuvre. The postoperative evolution was correct, without complications and the patient was discharged after 4 post-operative days. After 10 months, a new hepatic lesion is observed in segment 7, suggestive of metastasis. Presenting a volume reduction of the lesion in response to chemotherapy, it was decided a new intervention. The second video shows the atypical resection on segment seven. No important post-chirurgical adhesions are found except for some at the midline level and at the level of the preceding liver resection that can be easily removed. A tourniquet is easily placed through the foramen of Winslow to realize the Pringle manoeuvre in case it'd be needed. The right liver is partially mobilized for an optimal view of the lesion. The operation can be easily performed in 110 minutes, given the limited presence of postoperative adhesions, having previously been operated by laparoscopy. The Pringle manoeuvre is performed for 15 minutes, with minimal blood loss. The postoperative evolution is correct, discharging the patient 4 days later. Conclusion: This video shows the advantages of laparoscopy in the treatment of colorectal liver metastases. The minimal adhesions with this approach, makes easier the reinterventions that this patients usually need with similar morbidity and faster recovery.

Introduction/Objective Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN) is a rare hematologic malignancy of plasmacytoid dendritic cell precursors with an estimated incidence of 0.04 cases per 100,000 in the US. Given the cutaneous tropism of BPDCN, it should be differentiated from other CD56+ hematopoietic neoplasms with skin involvement such as CD56+ AML, extranodal NK/T-cell lymphoma, and other T-cell lymphomas. Methods/Case Report A 71-year-old male presented to the emergency department with asymptomatic, pink- violaceous plaques/nodules on the trunk for 3 months. One month prior, a dermatologist diagnosed epidermal inclusion cysts that were left untreated. The nodules progressed and a course of steroids prescribed by a primary care physician provided short term improvement before the lesions flared again. Review of systems and vitals were normal. Biopsies of representative lesions sent for histologic examination showed a diffuse dermal infiltrate of small to medium atypical cells with irregular nuclear contours, fine chromatin, one to several nucleoli and scant cytoplasm. Immunohistochemistry showed these cells were positive for CD2, CD4, CD56 and CD45 with strong expression of BCL2 and focal CD123. The cells were negative for CD3, CD20, CD79a, CD8, CD30, ALK-1, MUM-1, CD10, Cyclin- D1, C-MYC, EBER, BCL6, Langerin, Granzyme, TIA1, CD68, CD163, MPO, and Lysozyme. The histology and immunoprofile were consistent with BPDCN. A bone marrow biopsy showed cells with similar morphology and staining pattern, including expression of CD123.Treatment with chemotherapy and Tagraxofusp, was initiated. Within a week, the patient showed near resolution of cutaneous lesions. Repeat bone marrow aspirate and flow cytometry a month later showed no malignant cells. Results (if a Case Study enter NA) NA Conclusion We present this case as a rare hematologic malignancy with a challenging clinical and histopathologic diagnosis. The histologic findings suggested either a high grade myeloid or lymphoid malignancy. The combination of CD3-/CD56+/CD4+/CD123+ in the lesional cells helped establish the diagnosis of BPDCN, allowing for prompt treatment.