Background:Cough peak flow (CPF) is widely used for measuring voluntary cough intensity. However, the respective factors that affect CPF are not known. The aim of this study was to determine the factors affecting CPF by sex in community-dwelling adults.Method:We recruited participants using posters exhibited at a public gymnasium. Participation was voluntary, and all participants provided informed consent. Nonsmoking community residents (102 males, 49.6 ± 20.2 years of age; 101 females, 51.4 ± 18.4 years of age) participated in this study. The main outcome measures were sex differences in CPF, respiratory function, respiratory muscle strength, thorax extension, and grip strength. Factors affecting CPF by sex were analyzed using multiple regression analysis.Results:All parameters were higher in men than in women. CPF was affected by thorax expansion at the tenth rib, inspiratory muscle strength and forced expiration in 1 s in men, and thorax expansion at the tenth rib, inspiratory reserve volume, and expiratory muscle power in women. A weak negative correlation was observed between CPF and age (p = −0.24, p < 0.05) in women.Conclusions:The factors affecting CPF differed by sex in community-dwelling adults.Clinical Trial Number: UMIN000023912