The unique structural characteristics of threedimensional (3D) covalent organic frameworks (COFs) like high surface areas, interconnected pore system and readily accessible active sites render them promising platforms for a wide set of functional applications. Albeit promising, the reticular construction of 3D COFs with large pores is a very demanding task owing to the formation of interpenetrated frameworks. Herein we report the designed synthesis of a 3D non-interpenetrated stp net COF, namely TUS-64, with the largest pore size of all 3D COFs (47 Å) and record-low density (0.106 g cm À 3 ) by reticulating a 6-connected triptycenebased linker with a 4-connected porphyrin-based linker. Characterized with a highly interconnected mesoporous scaffold and good stability, TUS-64 shows efficient drug loading and controlled release for five different drugs in simulated body fluid environment, demonstrating the competency of TUS-64 as drug nanocarriers.
Three-dimensional (3D) covalent organic frameworks (COFs)
exemplify
a new generation of crystalline extended solids with intriguing structures
and unprecedented porosity. Notwithstanding substantial scope, the
reticular synthesis of 3D COFs from pre-designed building units leading
to new network topologies yet remains a demanding task owing to the
shortage of 3D building units and inadequate reversibility of the
linkages between the building units. In this work, by linking a tetragonal
prism (8-connected) node with a square planar (4-connected) node,
we report the first 3D COF with scu-c topology. The new
COF, namely, TUS-84, features a two-fold interpenetrated structure
with well-defined porosity and a Brunauer–Emmett–Teller
surface area of 679 m2 g–1. In drug delivery
applications, TUS-84 shows efficient drug loading and sustained release
profile.
Silver cluster-assembled materials (SCAMs) are emerging light-emitting materials with molecular-level structural designability and unique photophysical properties. Nevertheless, the widespread application scope of these materials is severly curtailed by their dissimilar...
The unique structural characteristics of three-dimensional (3D) covalent organic frameworks (COFs) like high surface areas, interconnected pore system and readily accessible active sites render them promising platforms for a wide set of functional applications. Albeit promising, the reticular construction of 3D COFs with large pores is a very demanding task owing to the formation of interpenetrated frameworks. Herein we report the designed synthesis of a 3D non-interpenetrated stp net COF, namely TUS-64, with the largest pore size of all 3D COFs (47 Å) and record-low density (0.106 g cm-3) by reticulating a 6-connected triptycene-based linker with a 4-connected porphyrin-based linker. Characterized with a highly interconnected mesoporous scaffold and good stability, TUS-64 shows efficient drug loading and controlled release for five different drugs in simulated body fluid environment, demonstrating the competency of TUS-64 as drug nanocarriers
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