Exactly twenty years ago, David Cogan of Harvard University, Department of Ophthalmology, reported four cases of "Nonsyphilitic Interstitial Keratitis Associated with Vestibulo-auditory Symptoms." All four cases came to him within a year, all from the environs of Boston. In his cases the corneal changes progressed rela tively little but the vestibular condition incapacitated the patients for several weeks or months and the auditory state led to profound deafness.Cogan discussed the differences between this disease and syphilitic keratitis, noting that in the latter condition, only 4% of the cases developed deafness and the deafness did not occur until months or years after the keratitis. Dr. Cogan and his associates have continued to report on these cases of non-syphilitic keratitis with vestibular and cochlear symptoms, as in 1949 when the case load had risen to 13, 1959 when two deaths but no autopsies were reported and 1963 when a limited autopsy on a 14 year-old boy was obtained.Reports of approximately 36 of these cases have come to our attention. They mostly concern relatively young people, although the age range is now ΐΥζ years to 60. Only one Negro and one Cuban are in the list. Reports have been in the Italian and Swiss literature. The disease was not listed on the program of a recent symposium in Philadelphia on vestibular diseases, October, 1964.

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