Paraduodenal herni ince barsak obstrüksiyonlarının nadir bir nedenidir. Sağ ve sol olarak ikiye ayrılır. Klinik semptomlar değişken, nonspesifik ve zaman zaman akut ince barsak obstrüksiyonu veya iskemisi şeklinde olabilir. Biz bu yazıda akut abdominal ağrı ve bulantı ile acil servise kabul edilen sol paraduodenal herni vakasını sunuyoruz.

Aim. Sepsis is the major cause of post-operative morbidity and mortality in obstructive jaundice as a result of bacterial translocation from the gut. This study was conducted to investigate the effect of beta-glucan in preventing bacterial translocation in an animal model where obstructive jaundice was developed by common bile duct ligation. Methods. Forty-five Wistar-albino rats were divided into three groups of fifteen animal each. Only laparotomy was administered to the first group. Bile duct ligation was administered to the second group. Bile duct ligation and oral beta-glucan for ten days were administered to the third group. The animals were sacrified at the end of the tenth day. Blood, liver, spleen and mesenteric lymph nodes were cultured. The samples taken from terminal ileum and liver were examined histopathologically. Aspartate transaminase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), total bilirubin, direct bilirubin and C-reactive protein (CRP) analyses were done on the blood samples taken from the rats. Results. In the first group bacterial translocation was observed in one animal whereas bacterial translocation was observed in twelve animals in II'nd group. In third group bacterial translocation was determined in six animals that received beta-glucan. The differences between these three groups were statistically significant (p<0.05). According to biochemical data only the decrease of ALP and total bilirubin values between group two and three were statistically significant (p<0.05). After the histopathological examination of liver and terminal ileum, no significant difference between group two and three was observed (p>0.05). Conclusion. The result of this study showed that beta-glucan, as a natural immune system activator, has an effect in preventing bacterial translocation in obstructive jaundice. Keywords: Obstructive jaundice, bacterial translocation, beta-glucan ÖzetAmaç. Sepsis, barsaktan kaynaklanan bakteriyel translokasyonun bir sonucu olarak tıkanma sarılığında post-operatif morbidite ve mortalitenin en önemli sebebidir. Bu çalışma, ortak safra kanalı ligasyonu yoluyla tıkanma sarılığı geliştirilen bir hayvan modelinde bakteriyel translokasyonun önlenmesinde beta-glukanın etkisi araştırmak için yapılmıştir. Yöntem. Kırk beş adet Wister albino rat, her birinde onbeş hayvanın bulunduğu üç gruba ayrıldı. I.gruba sadece laparatomi yapıldı. II. gruba safra kanalı ligasyonu yapıldı. III. gruba ise safra kanalı ligasyonu ve on gün beta-glukan oral verildi. Onuncu günün sonunda hayvanlar sakrifiye edildi. Kan, karaciğer, dalak ve mezenter lenf nodu kültürleri ekildi. Terminal ileum ve karaciğerden alınan örnekler histopatolojik olarak incelendi. Ratlardan alınan kan örneklerinden aspartate aminotransferaz (AST), alanine aminotransferaz (ALT), alkalin fosfatase (ALP), laktat dehidrogenaz (LDH), total bilirubin, direk Bilirubin ve C-reaktif protein (CRP) çalışıldı. Bulgular. Birincigrupta 1 hayvanda bakteriyel translokasyon gözlenirken, II. grup...