Introduction: Two effective factors on educational progress are students' educational skills and personality traits. Aim: This study aimed to anticipate educational progress of students of Shahid Beheshti University of Medical Science according to their educational skills and personality traits. Methods: this was a correlative descriptive study. sample of 250 students was selected by random cluster sampling method. Study tools included educational skills questionnaire and NEO Personality Inventory. Data analysis was conducted by multiple regression method. Results: the study results indicated that 43.1% of educational progress variance was explained by factors of educational skills among which controlling learning activity, concentration and selfefficacy,anticipated students' educational progress positively. Furthermore personality traits explained 23.4% of educational progress variance. Students' educational progress was anticipated negatively by neurosis and positively by extroversion and conscientiousness. Conclusion: the results suggested that it is feasible to anticipate students' educational progress according to their educational skills and personality traits. So to enhance students' academic performance it is necessary to consider factors of educational skills and personality traits along with other factors.