Objective: To investigate maternal adverse effects and perinatal and neonatal outcomes of women receiving coronavirus disease-2019 (COVID-19) vaccination during pregnancy. Material and Methods: Seven hundred and sixty pregnant women who were followed up in obstetrics outpatients were included in this prospective cohort study. COVID-19 vaccination and infection histories of the patients were recorded. Demographic data, including age, parity, and presence of systemic disease and adverse events following COVID-19 vaccination were recorded. Vaccinated pregnant women were compared with unvaccinated women in terms of adverse perinatal and neonatal outcomes. Results: Among the 760 pregnant women who met study criteria, the data of 425 pregnant women were analyzed. Among these, 55 (13%) were unvaccinated, 134 (31%) were vaccinated before pregnancy, and 236 (56%) pregnant women were vaccinated during pregnancy. Of those who were vaccinated, 307 patients (83%) received BioNTech, 52 patients (14%) received CoronaVac, and 11 patients (3%) received both CoronaVac and BioNTech. The local and systemic adverse effect profiles of patients who received COVID-19 vaccination either before or during pregnancy were similar (p=0.159), and the most common adverse effect was injection site pain. COVID-19 vaccination during pregnancy did not increase the ratio of abortion (<14 wk), stillbirth (>24 wk), preeclampsia, gestational diabetes mellitus, fetal growth restriction, second-trimester soft marker incidence, time of delivery, birth weight, preterm birth (<37 wk) or admission to the neonatal intensive care unit compared to the women who were not vaccinated during pregnacy. Conclusion: COVID-19 vaccination during pregnancy did not increase maternal local and systemic adverse effects or poor perinatal and neonatal outcomes. Therefore, regarding the increased risk of morbidity and mortality related to COVID-19 in pregnant women, the authors propose that COVID-19 vaccination should be offered to all pregnant women.

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Cystinuria is an inherited disease caused by a defect in renal and intestinal tubular transport affecting cystine and dibasic amino acids (lysine, ornithine and arginine). It is transmitted as an autosomal recessive disease. On fetal ultrasound, the colon is usually seen as hypoechoic or isoechoic. Antenatal hyperechoic appearance of the fetal colon was previously considered as a normal variant. However, recent studies have shown that hyperechoic colon is associated with cystinuria. We present a case of cystinuria, who was referred to us due to fetal hyperechogenic colon at 32 weeks of gestation. Additional fetal pericalyceal echogenic focal structures were observed on ultrasonography. The diagnosis of cystinuria was confirmed in the postnatal period.

OBJECTIVE: Aberrant right subclavian artery, which is detected in 1-1.5% of the population, is considered an anatomical variant. Aberrant right subclavian artery is usually not symptomatic, but can sometimes lead to dysphagia due to esophageal compression. On the other hand, it has been found that it has accompanied some fetal anomalies in the last two decades. Although aberrant right subclavian artery is seen at a rate of 1-1.5% in normal chromosomal fetuses, it is seen at a rate of 19-36%, especially in fetuses with Down syndrome. STUDY DESIGN: Our study was carried out in the Department of Obstetrics and Gynaecology at Ankara University Faculty of Medicine between the dates of January 2017-January 2020. Pregnant women have had their detailed ultrasonography at our clinic and who were between 18th-24th gestational weeks were included. Amniocentesis was performed on the patients who have accepted, and genetic results were followed up. The patients who did not accept were followed up until after birth, and genetic testing was requested for babies suggestive of anomaly. RESULTS: Our study included 6205 patients who underwent detailed ultrasonography in our clinic between January 2017 and June 2020. Our detailed ultrasonography application week was between 16-24 weeks. During this period, aberrant right subclavian artery was detected in 47 of our patients. The detection rate of ARSA in the normal population in our study was 0.7% (46/6205). While aberrant right subclavian artery was the only ultrasonographic finding in 28 patients, extra anomalies were observed in 18 patients. Down syndrome was detected in four fetuses, CONCLUSION: We did not find any chromosomal anomalies in any of the patients with isolated aberrant right subclavian artery. Therefore, we do not recommend invasive intervention in patients with isolated aberrant right subclavian artery. On the other hand, our study confirmed that aberrant right subclavian artery screening should be a part of a detailed fetal ultrasonographic examination. Further studies with larger patient groups are needed.

Amaç: Biz bu çalışmamızda, Türk popülasyonunda 11-14. gebelik haftaları için IT ve BPD persantil değerleri oluşturmayı ve intrakranial saydamlık ölçümünün fetal anomali ve gebelik komplikasyonlarını öngörmedeki etkinliğini araştırmayı amaçladık. Gereç ve Yöntemler: Çalışmamız retrospektif olarak Ocak 2022 - Nisan 2022 tarihleri arasında Tıp Fakültesi Perinatoloji polikliniğinde 535 hastanın verileri değerlendirilerek yapılmıştır. Gestasyonel yaş (GA), son adet tarihinin ilk gününden itibaren hesaplandı ve baş-popo uzunluğu (CRL) ölçülerek doğrulandı. CRL ölçümleri 45-84 mm arasında olan tekil gebelikler çalışmaya dahil edildi. Yapısal veya kromozom anomalisi olan, NT ≥3 mm olan, ultrasonografide spina bifida saptanan veya intrauterin ex fetüs saptanan gebelikler çalışma dışı bırakıldı. Bulgular: 535 gebe hasta değerlendirilmiş, 15 ikiz gebelik, yapısal veya kromozomal anomalili fetüsler (dördü kistik higroma, ikisi down sendromlu, ikisi ensefalosel ve biri vertebral anomalili), intrauterin ex fetüs (n=2) , NT ölçümleri ≥ 3 mm olan (n=5) toplam 31 gebe çalışma dışı bırakıldı. Geriye kalan 504 gebe, CRL ölçümleri 45-54 mm, 55-64 mm, 65-74 mm ve 75-84 mm olacak şekilde gruplandırılarak; IT ve BPD'nin 5., 50. ve 95. persentil değerleri hesaplanmıştır. Ayrıca IT ve BPD'nin 5., 50. ve 95. persentil değerleri, gebelik haftaları 11-11 hafta 6 gün ,12-12 hafta 6 gün, 13-13 hafta 6 gün ve 14-14 hafta 2 gün olarak gruplandırılarak hesaplanmıştır. Sonuç: İlk trimesterde BPD ve IT için belirlenen 95 persentil değerlerinin mevcut popülasyonda açık spina bifida, anöploidi ve yapısal kraniyal anomalilerin taranmasında kullanılabilecek pratik yöntemler olabileceğini düşünmekteyiz.