national A-T clinic in Nottingham. Here we present the results of the observational study of AFP levels. Methods Patients' paper and electronic clinical records were reviewed from 2006-2019 and data extracted. AFP levels of A-T patients who had a malignancy were compared with those who did not have any malignancy. Results Data were available for 77 patients age: 0.9 to 17.2 years; 38 (49.4%) females]. Six (7.8%) had a malignancy. AFP measurements (n=215) ranged from 4 to 1107 kU/L (normal range 0-10 kU/L). Mean AFP in those with a malignancy was 329.9 kU/L (range 6-541; SD 197.6) which was significantly higher than in those without malignancy at 228.8 kU/L (range 4-1107; SD 191.9, p 0.014). Conclusions The AFP levels were significantly higher in those with a malignancy than in those without malignancy. However, 70/71 children without malignancy had AFP levels in the tumour marker range. Time trend analysis is required to investigate if serial AFP measurements might be an early indicator of malignancy in A-T.

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national A-T clinic in Nottingham. Here we present the results of the observational study of AFP levels. Methods Patients' paper and electronic clinical records were reviewed from 2006-2019 and data extracted. AFP levels of A-T patients who had a malignancy were compared with those who did not have any malignancy. Results Data were available for 77 patients age: 0.9 to 17.2 years; 38 (49.4%) females]. Six (7.8%) had a malignancy. AFP measurements (n=215) ranged from 4 to 1107 kU/L (normal range 0-10 kU/L). Mean AFP in those with a malignancy was 329.9 kU/L (range 6-541; SD 197.6) which was significantly higher than in those without malignancy at 228.8 kU/L (range 4-1107; SD 191.9, p 0.014). Conclusions The AFP levels were significantly higher in those with a malignancy than in those without malignancy. However, 70/71 children without malignancy had AFP levels in the tumour marker range. Time trend analysis is required to investigate if serial AFP measurements might be an early indicator of malignancy in A-T.

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