Chronic inflammatory bowel disease (IBD) is often accompanied by intestinal and systemic symptoms that are bothersome and impair the quality of life of patients and their families. The main objective of this study is to evaluate the quality of life of IBD patients followed in the hepato-gastroenterology department of the TANGER-TETOUAN-ALHOCEIMA university hospital. Materials and methods: This is a descriptive cross-sectional study, carried out in the hepato-gastroenterology department of the TANGER-TETOUAN-ALHOCEIMA university hospital, which included all patients with IBD confirmed on endoscopic and histological criteria, and who presented for consultation during the period from March 2022 to December 2022. Patients with psychiatric disorders were excluded from the study. Quality of life was assessed using the Inflammatory Bowel Disease Questionnaire (IBDQ). The version used in our study has been translated into Moroccan dialectal Arabic and is currently being validated. Statistical and graphical analyses were performed using IBM SPSS Statistics 19 for Windows. Results: Our study included 100 patients with IBD. Crohn's disease was present in 62% of cases (n=62), and UC in 38% of cases (n=32). In our study, 24 patients (24%) were in remission at the time of data collection. The mean IBDQ-M score was 149.75, with extremes ranging from 66 to 217. Men had a higher mean score than women (155 versus 143; p=0.12). Patients aged over 50 had a lower score on average than patients aged under 50 (137 versus 150; p=0.3). CD patients had a better score than UC patients (152 versus 143; p=0.2). Patients in remission had a calculated sub-domain score of 61 versus 47 in relapsing patients, 28 versus 20 in the general symptoms sub-domain, 69 versus 50 for emotional functioning and 31 versus 25 for social functioning (p<0.001). Conclusion: Our study confirmed the impact of disease activity on HRQoL in IBD patients, irrespective of disease type.

Celiac disease is an autoimmune enteropathy, secondary to an allergy to gluten in genetically predisposed subjects, results in clinical polymorphism, with the presence of malabsorption syndrome, is a villous atrophy demonstrated using gastroscopy, which allows to biopsy the duodenal mucosa in order to demonstrate this atrophy at the histological level and also the demonstration of basal lymphocytosis, its associated clinical, endoscopic and histological abnormalities are positive for anti-ACs. IgA-type transglutaminase, the latter may be deficient, the chosen which is frequent in celiac patients compared to the general population, making sometimes the diagnosis is a challenge for the clinician. We report the case of an association between an IgA deficiency and celiac disease in a 20-year-old patient with no personal or family pathological history, revealed by diarrhea with signs of deficiency in connection with malabsorption and the presence of the sign suggestive at endoscopy. digestive system, with an analysis of the relationship between seronegative celiac disease (SNCD) and immunoglobulin A deficiency through a review of the literature on the main medical databases

The AIH-PBC overlap syndrome is the most common form of OS. The aim: to study the clinical and paraclinical characteristics of the overlap syndrome and to specify the therapeutic and evolutionary characteristics. Methods: The medical data of 42 PBC patients were evaluated for associated autoimmune hepatitis. Results: Among the 42 cases of PBC, we retained 16 cases of OS (37%). All female the association of diagnostic criteria for PBC and HAI was simultaneous in 80%. Treatment with AUDC, corticosteroid and Azathioprine was started in the majority of our patients. The course was marked by a complete (10 cases) or incomplete (n = 6) response. Conclusion: OS should be considered in the presence of any mixed cytolytic and cholestatic liver disease. Its recognition is essential in order to adapt treatment and prevent progression to cirrhosis and its complications.