The increasing insecticide resistant population of Anopheles gambiae S.l. mosquitoes in Nigeria and most of West Africa and other parts of the sub-saharan regions of Africa is becoming worrisome and currently, it’s becoming a threat to the tools widely used for vector control. Though, resistance developed faster in most areas where pyrethroids previously, has been tried alone than those places tried with other earlier applications such as Organophosphates, Organochlorine and the Carbamates group inclusive.The higher coverage of indoor residual spraying (IRS) is suggestive of effective susceptibility in vector species of Anopheles tried in Nasarawa state, Nigeria using Inesfly Carbapaint 10 (Propoxur 1.0 w/w) insecticidal paint. The wall cone bio-assay used, a primer was employed to prime a cemented plaster surface and wooden board under laboratory condition within the 24–48hours before the paint application. The primer was allowed to get dried up within a given time frame before the Inesfly Carbapaint 10 (Propoxur 1.0% w/w) insecticidal paint was applied at the dosage of 8m2/L for cement plaster surface and wooden board drying at room temperature for 5 consecutive days. The wall-cone bio-assay and the varied wall cemented plaster surface parameters of 0.5ml, 1.0m and 1.5m and wooden board were both treated with 1.0% propoxur painted substrates in 24hours post exposure to validate 6months post application. The bio-efficacy and durability of indoor residual treatment with propoxur 1.0% w/w insecticidal paint from february to July, 2018 (6months) were shaded on the primer substrate. The wild Anopheles gambiae mosquitoes after 24hours of observation, showed 100% knockdown/mortality at varied cone-bioassay wall parameters height. Monthly distribution gave susceptibility result treatment with low toxicity effect, and the results presented as Mean ± standard deviations of triplicate observations (100.00±0.00). From the tried result under laboratory strain condition, with increased in those risk from malaria with indoor residual spraying (IRS) admixed microencapsulated insecticidal paint have proven positive result activities and broad spectrum against insects and agricultural pests with greater hope to public health and decreasing in cases of malaria transmission. Indeed, the carbamates based insecticides is on the most preferred in the fight against malaria vector as such, should further paired or synergize with other affluent pyrethroids based to intensify were possible, high level of susceptibility, knockdown, hoping that new-age additional classes of insecticides (Pyrrole and Neonicotinoid) will become available for the control of adult mosquito.