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The findings demonstrate the feasibility and therapeutic potential for hypoglossal nerve stimulation in obstructive sleep apnea.

R Re ed du uc ct ti io on n i in n s sy ym mp pa at th he et ti ic c a ac ct ti iv vi it ty y a af ft te er r l lo on ng g--t te er rm m C CP PA AP P t tr re ea at tm me en nt t i in n s sl le ee ep p a ap pn no oe ea a: : c ca ar rd di io ov va as sc cu ul la ar r i im mp pl li ic ca at ti io on ns s It is concluded that obstructive sleep apnoea is associated with high sympathetic activity both during sleep and waking periods. Urinary metanephrine excretion seemed to reflect blood pressure, but neither daytime nor night-time catecholamine excretion was directly related to disease severity in patients with severe obstructive sleep apnoea. In spite of a marked reduction of catecholamine excretion at followup, BP and cardiac structure remained unchanged. Although increased sympathetic activity may act as a contributory trigger for cardiovascular disease in sleep apnoea, a reduction of activity after nasal CPAP is not associated with changes in blood pressure or cardiac structure.

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