Objective: to analyze the relationship between PE and the newborn hearing loss Method : Analytic observation research withcross sectionaldesign performed inRSMHPalembangsince December 2016 to July 2017, obtained 48 aterm neonates born from mother diagnosed with PE (11 PE and 37 severe PE). Measurements of neonatal hearing loss then performed using emission otoacoustics (OAE) in both ears by ENT division with catagories intepretation of pass and refer. The mothers were physically check and interviewed to obtain demographic data and obstetric history. After the data normality were proved byShapiro Wilktest, we performed bivariate analysis using X2test on demographic and obstetric characteristics of the mother, neonatal demographic characteristics, and determine the relationship of PE with OAE result. The ratio of systolic (SBP) and diastolic (DBP) blood pressure to neonatal hearing loss was determined by independent T test and ROC test. Multivariate analysis was performed to determine the maternal and neonatal risk factors that influenced neonatal hearing loss. Data analysis using SPSS version 18.0. Results : There were no significant differences in maternal and neonatal demographic characteristics in neonatal hearing loss (p> 0.05). No significant relationship was found between PE and OAE of both ear (right, p = 0,437; left, p = 0,368). There was difference of mean of SBP and DBP of mother inneonate OAE of both ears (p <0,05) with cut off point of SBP 160 mmHg and DBP 106 mmHg.There was a significant association between DBP (> 106 mmHg) of the mother and birth weight of the fetus (< 2500 g) with referOAE. Conclusion: There was a significant association between neonatal hearing loss and maternal PE, determined primarily by maternal DBP, and neonatal birth weight. Keywords: maternal blood pressure, OAE,preeclampsia, Abstrak Tujuan: untuk menilai hubungan PE ibu dengan penurunan pendengarah bayyi baru lahir Metode: Penelitian observasi analitik dengan disain cross sectionaldilakukan di RSMH Palembang sejak Desember 2016 sampai Juli 2017, diperoleh 48 neonatus aterm lahir dari ibu PE (11 PER dan 37 PEB). Neonatus dilakukan pengukuran pendengaran menggunakan otoakustik emisi (OAE) pada kedua telinga oleh divisi THT dengan kategori intepretasi refer dan pass. Ibu dilakukan pemeriksaan dan wawancara untuk memperoleh data demografi dan riwayat obstetri. Setelah normalitas data dibuktikan dengan tes Saphiro Wilk, dilakukan analisis bivariat menggunakan tes X2 pada karakteristik demografi dan obstetri Ibu, karakteristik demografi neonatus, dan menentukan hubungan preeklampsia dengan hasil OAE. Perbandingan tekanan darah sistolik (TDS) dan diastolik (TDD) terhadap penurunan pendengaran neonatus ditentukan dengan independent T test dan uji ROC. Analisis multivariat dilakukan untuk menentukan faktor risiko Ibu maupun neonatus yang berpengaruh terhadap penurunan pendengaran neonatus. Analisa data menggunakan SPSS versi 18.0. Hasil: Tidak ditemukan perbedaan signifikan karakteristik demografi Ibu maupun neonatus tehadap penurunan pendengaran neonatus (p>0,05). Tidak ditemukan hubungan signfikan antara kondisi PE dengan OAE kanan (p = 0,437) dan kiri (p = 0,368). Ditemukan perbedaan rerata TDS dan TDD ibu terhadap OAE kedua telinga neonatus (p<0,05) dengan cut off point TDS 160 mmHg dan TDD 106 mmHg. Ditemukan hubungan signifikan antara TDD (>106 mmHg) ibu dan berat lahir janin (>2500 gr) dengan OAE refer. Kesimpulan: Terdapat hubungan bermakna antara penurunan pendengaran neonatus dengan kondisi preeklampsia ibu, yang ditentukan terutama oleh TDD ibu, serta berat lahir bayi. Kata kunci:, OAE, preeklamsia, tekanan darah
Objective: Knowing the effectiveness of high doses of calcium in preventing preeclampsia.Methods: Experimental analytical study with Randomized Controlled design Single-blind trial in the form of survival analysis (survival analysis) in the period June 2018 - May 2019 in fetomaternal outpatients clinic in Mohammad Hoesin Hospital, PalembangResults: The mean hemoglobin level at the last visit found that the average hemoglobin level between the two groups was 12.81 in the high calcium group and 12.61 in the low calcium group, while the mean hematocrit level between the two groups was 35.17 in the high calcium group and 34.84 in the low calcium group and the respective calcium levels each group is 10.1. In this study, after high calcium intervention, no pregnant women with preeclampsia were found, whereas in the low-dose calcium intervention group it was found that 3 of 17 patients (17.7%) had preeclampsia. With the McNemar test it was found that there was no difference in the incidence of preeclampsia both after highdose calcium and low-dose calcium interventions (p = 0.250).Conclusions: High-dose calcium (1.5g - 2g) is effective in preventing preeclampsia and there was no difference in effectiveness between administration of high-dose calcium with low-dose calcium administration to the incidence of preeclampsia.Keywords: high dose calcium, preeclampsia, randomized control trial. AbstrakTujuan: Mengetahui efektivitas pemberian kalsium dosis tinggi dalam mencegah preeklamsia.Metode: Penelitian analitik eksperimental dengan desain randomized controlled trial single blind dalam bentuk ujian alias kesintasan (survival analysis) dalam kurun waktu Juni 2018 – Mei 2019 di Poliklinik Fetomaternal Rumah Sakit Umum Pendidikan Mohammad Hoesin, PalembangHasil: Rerata kadar hemoglobin pada kunjungan terakhir didapatkan rerata kadar hemoglobin antara kedua kelompok adalah 12,81 pada kelompok kalsium tinggi dan 12,61 pada kelompok kalsium rendah, sedangkan rerata kadar hematokrit antara kedua kelompok adalah 35,17 pada kelompok kalsium tinggi dan 34,84 pada kelompok kalsium rendah dan rerata kadar kalsium masing-masing kelompok adalah 10,1. Pada penelitian ini setelah intervensi kalsium tinggi tidak ditemukan ibu hamil yang mengalami preeklamsia, sedangkan pada kelompok intervensi kalsium dosis rendah ditemukan 3 dari 17 pasien (17,7%) menderita preeklamsia. Dengan uji Mc Nemar didapatkan hasil tidak terdapat perbedaan kejadian preeklamsia baik setelah intervensi kalsium dosis tinggi maupun kalsium dosis rendah (p = 0,250). Hal ini berarti kalsium dosis tinggi dan rendahefektif untuk mencegah preeklamsia.Kesimpulan: Kalsium dosis tinggi (1,5g – 2g) efektif dalam mencegah preeklamsia dan tidak ditemukan perbedaan efektivitas antara pemberian kalsium dosis tinggi dengan pemberian kalsium dosis rendah terhadap kejadian preeklamsia.Kata kunci: kalsium dosis tinggi, preeklamsia, randomized control trial.
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