In drug development, determination of its toxic profile is paramount and usually the initial step in its evaluation. Phytochemical constituent's assessment can subsequently be muricata is an evergreen shrub that is endowed with ethno source of food. The significant needs to evaluate the toxic profile of the plant lead to the design of this work. Therefore this work is desi as the index) and sub-chronic toxicity profile of the leaf extracts. serum levels of some biochemical parameters which include alkaline phosphatase (ALP), alanin aminotransferase (ALT) and aspartate aminotransferase (AST). Also include the effect on the kidney function parameters such as Urea, creatinine and electrolyte (K+, Na+, Cl LD 50 of the extract indicated that the plant extract is relatively safe with no mortality recorded at dose >5000mg/kg body weight of the drug. There was no significant (P difference in the serum level of ALP ALT and AST for the liver functi significant variation recorded on the kidney function parameters. However, salient mild effect on the liver and kidney was observed from the histopathological examination, but can be effectively averted if extended use of higher concentration of the extract is avoided, as the effect is observed to be both concentration and time dependent. suggested, the possible hepato-protective and neuphro extract which should be further investigated