This study aimed to evaluate the clinical, haematobiochemical and histopathological changes in goats with surgically induced unilateral hydronephrosis. To achieve this aim eight male castrated goats were divided into two groups. Group A (animals with surgically-induced unilateral hydronephrosis) in which goats were subjected to ligation of the right ureter for 42 days and group B (sham-operated). Clinical examination and haematobiochemical analysis were performed before and after induction (on days 1, 7, 14, 21, 28, 35 and 42). Histopathological examination of kidneys was carried out at the end of the study. On the 1 st day goats with unilateral hydronephrosis showed depression, arched back, decreased appetite. After that, these clinical signs were ameliorated and the animals restored their apparent health condition. PCV%, Hb content and RBCs count increased during the early periods of the study then returned gradually to normal level by the end of the study. WBCs count was significantly increased allover the time of the study. Significant increase of serum urea, creatinine, uric acid and calcium levels during the early period of the study then gradually decrease. Albumin and total proteins levels were initially decreased but were restored by the end of the experiment. Post-mortem examination of affected kidneys showed dilatation of renal pelvis and calyces with severe atrophy of the parenchyma. Histopathological examination of affected kidneys revealed severe cystic dilatation of renal tubules and intertubular connective tissue proliferation. We concluded that unilateral hydronephrosis produced significant changes during the early stage, which were gradually restored owing to the compensatory activities of the contralateral kidney.

Nephrotoxicity is the main problem associated with gentamicin. So this work aimed to evaluate the effect of Vitamin C on gentamicin -induced nephrotoxicity in Baladi goats (Capra hircus) based on the clinical, haematobiochemical and histopathological changes. To achieve this aim, ten clinical healthy Baladi goats were allotted into two groups, each of five. The first group was gentamicin-induced nephrotoxicity that injected with gentamicin while, the second group was injected with Vitamin C along with gentamycin. Jugular blood samples were collected at 0, 7, and 12 days post gentamycin injection. Dullness, decreased appetite and unable to stand and lie down were the main signs exhibited after gentamicin injection. However, these signs did not appear in Vitamin C treated goats. In addition, there was significant increase in serum urea, creatinine and serum MDA. While hematological examination showed a significant decrease in Hb content and RBCs content and erythrocyte SOD. In the meantime, histopathological examinations revealed severe renal damage. Marked improvement in the haematobiochemical changes were detected in gentamicin Vitamin C treated goats with mild renal damage. Our results suggest the cytoprotective role of Vitamin C on gentamicin-induced nephrotoxicity in goats that could be attributed to its anti-oxidant activity, a result of high importance in clinical application.

A B S T R A C TThe study aims to assess the relation between oxidative stress, antioxidant activity and post parturient hemoglobinuria on 70 hemoglobinuria and 30 apparently healthy buffaloes. Blood and serum samples were collected and tested for various parameters of oxidative stress and antioxidant enzymes. Significant increase in erythrocytic MDA (malondialdehyde) whereas significant decrease in serum inorganic phosphorus, copper (Cu), selenium (Se), erythrocytic SOD (superoxide dismutase), GPX (glutathione peroxidase) and G6PD (glucose-6-phosphate dehydrogenase). According to these results, there was increase in oxidative stress indicator while antioxidant enzymes activities dramatically decreased in post parturient hemoglobinuria (PPH) affected buffaloes. It was concluded that there is relation between oxidative stress, antioxidant activity and PPH in buffaloes.

This study was carried out to estimate the haematological, serum biochemical and urological alterations associated with post parturient haemoglobinuria (PPH) on 70 haemoglobinuria and 30 apparently healthy buffaloes. Blood, serum and urine samples were collected and tested for various haematological, biochemical and urological parameters. Significant decrease in total erythrocyte count, Hb concentration, PCV %, lymphocyte%, serum inorganic phosphorus, total protein, albumin, glucose whereas significant increase in neutrophils%, serum urea, creatinine, total bilirubin and alkaline phosphatase. In PPH colour of urine in haemoglobinuria buffaloes ranged from red, dark red to coffee colour. Analysis of urine samples by Reagent urine strips showed positive for haemoglobin and protein. It was concluded that post parturient haemoglobinuria causes severe alterations in hematobiochemical and urological parameters in buffaloes.