The qualitative information about the interaction between 2-{[p-chlorophenylimino]methyl}phenol as attracting chelating Schiff base ligand (HL) with cobalt(II) and manganese(II) ions have been discussed by using the data of spectroscopy (IR, UV-Visible) and 1H NMR resonance techniques. The electrochemical properties of these species have been carried out by using cyclic voltammetry studies to see the differences in the potential and activity behavior during and after the electron transfer process. The cyclic voltammetry behavior of ligand exhibited an irreversible one-electron transfer and redox diffusion-controlled process due to the linearity relationship between redox peaks current and square root of scan rates. The cyclic sweep for CoL and CoL2 complexes appeared two irreversible oxidation peaks but with different values and positions, while the cyclic sweep of MnL and MnL2 complexes appeared several redox peaks, which related to the formation of various manganese redox species. All complexes had a deviation of current and potential to more anodic values when the cyclic sweep was applied at different scan rates. A positive shift was observed for CoL2 and MnL2 complexes may be to the electron-donating and electron-withdrawing properties of phenyl substituted group.

This work aimed to synthesize, characterize and evaluate the thermal stability of new sulfur and selenium organochalcogenide derivatives and to test the cytotoxic activity against breast adenocarcinoma cell line (MCF-7) through conducting MTT assay and AO/EB dual staining-technique. Two series of ten organo-chalcogen compounds: 4-(substituted)phenylthiomorpholine-3,5-dione and 4-(substituted)phenylselenomorpholine-3,5-dione were prepared by the reaction of Na2S·3H2O and NaHSe with N-(substituted)phenyl-2-chloro-N-(2-chloroacetyl)acetamide, respectively, under nitrogen atmosphere to give the corresponding cyclic chalcogenide ligands. All new compounds were characterized by melting point, FTIR, elemental analysis, UV-Visible, 1H-NMR and 13C-NMR. Meanwhile, TG/DTA analysis of some of these ligands was conducted to evaluate the thermal stability, kinetic, and characteristic thermodynamic parameters. Absorption spectroscopy was used to investigate these compounds with human DNA. The experimental results investigated a hypochromic effect via intercalation binding mode. The role of the prepared ligands in breast cell lines has been investigated by conducting MTT assay via spectroscopic techniques on HBL100 and MCF-7, normal and cancer breast cell lines, respectively. Cell death was seen after AO/EB dye staining method employing the fluorescence microscopy technique. The results revealed that these compounds possess cytotoxic activity on the MCF-7 and HBL-100 cell lines at a fixed concentration.

Complexes of Cu(II), Co(II) and Mn(II) with two Schiff base ligands {[(2-carboxyphenyl) imino]methyl} phenol (HLA) and {[(2-hydroxyphenyl)imino]methyl} phenol (HLB) were synthesized and characterized by FT-IR, UV-Visible, 1 H NMR spectroscopy and elemental analysis. All the synthesized complexes have been evaluated for their thermal degradation studies using TG-DTA analytical methods in static air. Thermodynamic and kinetic parameters were evaluated from the TG-DTA curves using Arrhenius equation.

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